NCT07202455Not yet recruiting
Effect of Early Neuromodulation Coupled With Rehabilitation on the Prevention of Post-stroke Pain
Source: ClinicalTrials.gov · Last updated 23 Dec 2025
Brief summary (registry, in English)
This is a prospective clinical study to evaluate the efficacy of tDCS stimulation, coupled with conventional rehabilitation, on the development of post-stroke neuropathic pain. The study involves a double-blind, randomized, sham-controlled experimental protocol involving 2 parallel groups with patients allocated according to a Fleming design (40 patients in the active group, 20 patients in the control group). The study is aimed at sub-acute post-stroke patients. After recruitment, they will receive 10 sessions of tDCS stimulation (2mA, 20 minutes with a current on/off ramp of 0.1 mA/s). For the control group, stimulation will stop after the current ramp.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 16 Sept 2025
- Start date
- 1 Jan 2026
- Primary completion date
- 30 Apr 2029
- Lead sponsor
- University Hospital, Clermont-Ferrand
- Diseases
- Stroke
- NCT number
- NCT07202455
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 1 Jan 2026 to the primary completion date, 30 Apr 2029
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients participating in another research protocol involving a drug in the 30 days prior to inclusion
- Drug or psychoactive substance abuse
Other illness
- Contraindication to tDCS (epilepsy/history of epilepsy, intracranial ferromagnetic material or implanted stimulator, acute eczema or irritated skin over the stimulation area)
- Patients with Parkinson's disease
- Severe psychiatric disorders (e.g., schizophrenia)
- Any tumor disease with a life expectancy of \<1 year
Other
- Contraindication to MRI (use of a pacemaker or insulin pump, wearing of a metal prosthesis, intracerebral clip or piercing, claustrophobia)
- Cognitive or language difficulties preventing comprehension of instructions and/or correct clinical assessment
- Pregnant or breast-feeding women
- Patients under guardianship or curatorship, deprived of liberty, safeguard of justice
- Major depression
- The presence of pre-existing lesions \>1.5 cm (maximum diameter) in a cerebral area belonging to the anatomically defined sensorimotor system
- Alcohol abuse
- Increased intracranial pressure
- Patients with a medical device containing electronics or conductive materials
- Patients on continuous oxygen (system not adapted)
Who the study is looking for
- Age ≥18 years
- Ischemic or hemorrhagic stroke confirmed by MRI or scanner
- Lesion(s) in somato-sensory areas (i.e. mainly in: the pons, thalamus, internal capsule, basal ganglia and operculo-insular regions)
- Sensory and/or motor deficit requiring rehabilitation
- Subacute stage (7 to 45 days post-stroke)
- No neurological deficit or chronic neuropathic pain prior to stroke
- No neuropathic pain at inclusion
- Patient can be followed throughout the study.
- Information letter read and understood
- Able to give informed consent to participate in research
- Affiliation with a social security scheme
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Clemront-Ferrand Coordinator of this site? Confirm its status | Clermont-Ferrand | France | Unknown status |
| CH Etienne Clémentel Coordinator of this site? Confirm its status | Enval | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.