NCT07202819Recruiting
Effect of Neoadjuvant Chemotherapy on MRI Accuracy Before Cystectomy
Does Neoadjuvant Chemotherapy Affect the Accuracy of Magnetic Resonance Imaging Before Radical Cystectomy? A Randomized Controlled Trial.
Source: ClinicalTrials.gov · Last updated 2 Oct 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The goal of this clinical trial is to learn if neoadjuvant chemotherapy (NAC) affects the accuracy of magnetic resonance imaging (MRI) in staging muscle-invasive bladder cancer (MIBC). This study will also assess how tissue changes induced by NAC impact MRI interpretation. The main questions it aims to answer are: Does NAC compromise the accuracy of MRI in staging MIBC? Does NAC-induced tissue change affect the reliability of MRI in tumor assessment? Researchers will compare MRI staging accuracy in MIBC patients who received NAC to those who went directly to surgery, to see if NAC impacts MRI's diagnostic performance. Participants will: Undergo MRI scanning before surgery Receive either NAC or go directly to surgery, depending on their group assignment Have their MRI results compared to histopathological outcomes after surgery
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 76 (estimated)
- First submitted
- 24 Sept 2025
- Start date
- 1 Sept 2025
- Primary completion date
- 20 May 2026
- Lead sponsor
- Assiut University
- Diseases
- Bladder cancer
- NCT number
- NCT07202819
What you commit to
- Study type: Interventional
- Planned participants: 76
- From 1 Sept 2025 to the primary completion date, 20 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who have received pelvic radiotherapy.
- Previous open or laparoscopic pelvic surgery.
Other
- Patients with contraindications to MRI.
- Patients who are unfit for or refuse radical cystectomy.
- Ineligibility to cisplatin.
- squamous differentiation in the histopathology
Who the study is looking for
- Patients diagnosed with cT2 urothelial carcinoma of the urinary bladder, according to the TNM classification, who give informed, written consent on participation in the study and approve all its requirements.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Urology Department, Faculty of Medicine, Assiut University Coordinator of this site? Confirm its status | Asyut | Egypt | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.