NCT07203768Recruiting
A ELN-Multicenter Study on Phenotypic Evolution and Clinical Outcomes
Unmasking Polycythemia Vera in Long-Standing Essential Thrombocythemia: A ELN-Multicenter Study on Phenotypic Evolution and Clinical Outcomes
Source: ClinicalTrials.gov · Last updated 9 Jul 2026
Brief summary (registry, in English)
International multicenter retrospective observational study consisting of two parts: a nested case-control study (part A) and a comparative retrospective cohort study (part B).
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 678 (estimated)
- First submitted
- 23 Sept 2025
- Start date
- 1 Dec 2025
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
- Diseases
- Myeloproliferative neoplasms
- NCT number
- NCT07203768
What you commit to
- Study type: Observational
- Planned participants: 678
- From 1 Dec 2025 to the primary completion date, 31 Dec 2026
- 24 sites in 5 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- None.
Who the study is looking for
- \- ET patients (diagnosed according to "International consensus classification of myeloid neoplasms and acute leukemias - 2022" criteria) who are JAK2V617F positive and have progressed to PV (diagnosed according to "International consensus classification of myeloid neoplasms and acute leukemias - 2022" criteria) by 31/12/2020. The date of PV diagnosis will be defined as the index date and this group of patients will be defined as ET-to-PV cases.
Age in the registry: 18 years to 100 years · Sex: All · Does not accept healthy volunteers
Sites (24)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Halle Coordinator of this site? Confirm its status | Halle | Germany | Not yet recruiting |
| Hannover Medical School Coordinator of this site? Confirm its status | Hanover | Germany | Recruiting |
| University Clinic for Hematology, Oncology, Hemostaseology and Palliative Care Johannes Wesling Medical Center Coordinator of this site? Confirm its status | Minden | Germany | Recruiting |
| IDIBAPS, Hospital clinic Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| 12 Octubre University Hospital Coordinator of this site? Confirm its status | Madrid | Spain | Recruiting |
| Guy's and St Thomas' NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| A.S.O. SS. Antonio e Biagio e C.Arrigo, SC Ematologia Coordinator of this site? Confirm its status | Alessandria | Italy | Not yet recruiting |
| ASST Papa Giovanni XXIII, SC Ematologia Coordinator of this site? Confirm its status | Bergamo | Italy | Recruiting |
| Policlinico S. Orsola Malpighi Coordinator of this site? Confirm its status | Bologna | Italy | Not yet recruiting |
| ASST Spedali Civili Coordinator of this site? Confirm its status | Brescia | Italy | Not yet recruiting |
| AOU Careggi, Divisione di Ematologia Coordinator of this site? Confirm its status | Florence | Italy | Recruiting |
| Ospedale San Raffaele Coordinator of this site? Confirm its status | Milan | Italy | Not yet recruiting |
| ASST Grande Ospedale Metropolitano Niguarda, Divisione di Ematologia Coordinator of this site? Confirm its status | Milan | Italy | Not yet recruiting |
| Fondazione IRCCS Cà Grande - Op. Maggiore Policlinico Coordinator of this site? Confirm its status | Milan | Italy | Not yet recruiting |
| ASST MONZA Ospedale San Gerardo Clinica Ematologica Coordinator of this site? Confirm its status | Monza | Italy | Not yet recruiting |
| Azienda Ospedaliera Universitaria Federico II di Napoli Divisione di Ematologia e Trapianti del Midollo Coordinator of this site? Confirm its status | Naples | Italy | Not yet recruiting |
| Azienda Ospedaliero Universitaria Maggiore della Carità di Novara SCDU Ematologia Coordinator of this site? Confirm its status | Novara | Italy | Recruiting |
| Divisione Ematologia, Fondazione IRCCS Policlinico San Matteo Coordinator of this site? Confirm its status | Pavia | Italy | Not yet recruiting |
| Presidio Ospedaliero di Pescara Coordinator of this site? Confirm its status | Pescara | Italy | Not yet recruiting |
| Fondazione Policlinico Universitario Gemelli Coordinator of this site? Confirm its status | Roma | Italy | Recruiting |
| Umberto I Policlinico Coordinator of this site? Confirm its status | Roma | Italy | Not yet recruiting |
| Azienda Ospedaliera Universitaria Integrata - Ospedale Borgo Roma, Unità di Ematologia Coordinator of this site? Confirm its status | Verona | Italy | Not yet recruiting |
| Divisione Ematologia, Ospedale San Bortolo Coordinator of this site? Confirm its status | Vicenza | Italy | Recruiting |
| Mayo Clinic Coordinator of this site? Confirm its status | Rochester | United States | Active, not recruiting |
Related publications
- From essential thrombocythemia to polycythemia vera (ET-2-PV): rationale and design of a multicenter ELN study.Ann Hematol · 2026 · PMID 41776088
This page is information, not medical advice. Discuss any trial with your doctor.