NCT07204652Recruiting
Colonoscopic Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis
Detection of Phosphorylated Alpha-synuclein Through Routine Colonoscopy to Diagnose Parkinson's Disease and Related Disorders
Source: ClinicalTrials.gov · Last updated 11 Feb 2026
Brief summary (registry, in English)
The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease. The main question it aims to answer is: Can doctors find a protein called alpha-synuclein in colon tissue samples from people with Parkinson's disease? Currently, Parkinson's disease is diagnosed by observing symptoms like tremors and movement problems, but by then the disease has already progressed significantly. Earlier detection could help doctors start treatment sooner.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 20 (estimated)
- First submitted
- 24 Sept 2025
- Start date
- 3 Sept 2025
- Primary completion date
- 30 Sept 2028
- Lead sponsor
- CND Life Sciences
- Diseases
- Parkinson disease
- NCT number
- NCT07204652
What you commit to
- Study type: Observational
- Planned participants: 20
- From 3 Sept 2025 to the primary completion date, 30 Sept 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of colon cancer
- Recent gastrointestinal illness or surgical procedures
- Significant cognitive impairment, as determined by study investigators
Other
- Use of anticoagulants (Plavix 75 mg or aspirin up to 325 mg alone is allowed)
- Pregnant or planning to become pregnant before the scheduled colonoscopy
- Decisionally impaired adults who cannot express understanding that this study is voluntary and for research purposes
Who the study is looking for
- Adults 40 to 99 years of age
- Patients with a confirmed clinical diagnosis of Parkinson's disease by UKPDS Brain Bank Criteria
- Patients who have agreed to undergo a routine colonoscopy as part of their surveillance for colon cancer or exclusion of other gastrointestinal diseases
Age in the registry: 40 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Oregon Health Science University Coordinator of this site? Confirm its status | Portland | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.