NCT07208123Not yet recruiting
Mechanistic Studies of Chronic COPD Using Single-Cell Sequencing and Single-Cell Spatial Transcriptomics
A Bidirectional Cohort Study of Single-Cell Sequencing and Single-Cell Spatial Transcriptomics in Chronic COPD
Source: ClinicalTrials.gov · Last updated 6 Oct 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This study is an ambispective cohort study, the sample from patients were from both previously stored and freshly collected . The objective of this study is to investigate the molecular pathological changes underlying the development of chronic obstructive pulmonary disease (COPD). We will use single cell sequencing technology to analyze lung tissue samples from patients who underwent lung resection, with lung tissue from patients without COPD serving as controls. This research aims to provide insights into the pathogenesis of COPD.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 150 (estimated)
- First submitted
- 27 Sept 2025
- Start date
- 30 Sept 2025
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Tongji University
- Diseases
- COPD
- NCT number
- NCT07208123
What you commit to
- Study type: Observational
- Planned participants: 150
- From 30 Sept 2025 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receiving systemic immunosuppressive medications such as anti-rejection drugs;
Other illness
- Diagnosed with asthma according to the GINA 2023 guidelines and with a history of asthma exacerbations within the past year;
- Combined with Advanced lung cancer;
Other
- Improper preservation of pathological specimens, refusal to consent to sample collection, or incomplete clinical information；
- Combined with other factors causing obstructive airflow limitation;
Who the study is looking for
- Receiving lung resection surgery at the hospital for any reason；
- Diagnosed with COPD according to the 2024 GOLD guidelines；
- Tissue samples that meet collection requirements and are either agreed to be collected or already preserved；
Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Renji Hospital Shanghai Jiao Tong University School of Medicine Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.