NCT07208786Recruiting
Pre-emptive Endoscopic Vacuum Therapy Reduces the Incidence of Anastomotic Leakage After Colorectal Cancer Surgery
Randomized Clinical Trial on Pre-emptive Endoscopic Vacuum Therapy Versus Conventional Management for the Prevention of Anastomotic Leakage After Colorectal Cancer Surgery
Source: ClinicalTrials.gov · Last updated 2 Nov 2026
Brief summary (registry, in English)
Evaluate the safety and efficacy of postoperative Pre-emptive EVT (PEVT) in reducing the incidence of anastomotic leaks within 30 days after surgery in patients with colorectal cancer. Compare the differences between the PEVT group and the control group in terms of operation time, length of hospital stay, and total medical costs. Analyze the incidence of other postoperative complications in the two groups, such as wound infection, abdominal abscess, and intestinal obstruction. Assess the impact of PEVT on postoperative recovery indicators, including time to first flatus, time to first defecation, and time to ambulation. Observe the occurrence of PEVT-related adverse events, such as device displacement, bleeding, and infection.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 110 (estimated)
- First submitted
- 28 Sept 2025
- Start date
- 22 Sept 2025
- Primary completion date
- 10 Oct 2026
- Lead sponsor
- Nanchong Central Hospital
- Diseases
- Colorectal cancer
- NCT number
- NCT07208786
What you commit to
- Study type: Interventional
- Planned participants: 110
- From 22 Sept 2025 to the primary completion date, 10 Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Preexisting anastomotic leakage or severe intra-abdominal infection before surgery.
- Complicated by severe cardiovascular or cerebrovascular diseases (e.g., acute myocardial infarction, acute phase of cerebral infarction).
- History of abdominal radiotherapy or multiple abdominal surgeries leading to severe intra-abdominal adhesions.
- Complicated by other malignant tumors and currently undergoing radiotherapy or chemotherapy.
- Psychiatric illness or cognitive impairment preventing compliance with the study.
Lab values
- Severe liver or kidney dysfunction (liver function Child-Pugh class C, creatinine clearance \<30 ml/min).
- Coagulation disorders (platelets \<50×10⁹/L, INR \>1.5) or receiving anticoagulant therapy that cannot be adjusted.
Who the study is looking for
- Pathologically diagnosed with colorectal cancer, planned for radical surgery (right hemicolectomy, left hemicolectomy, or anterior resection of the rectum, etc.).
- Age 18-85 years, American Society of Anesthesiologists (ASA) classification I-III.
- Anastomosis to be performed in a single stage (meeting anastomotic criteria).
- Patient or legal guardian is able to understand and sign the informed consent form and comply with follow-up.
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nanchong Central Hospital Coordinator of this site? Confirm its status | Nanchong | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.