NCT07213245Recruiting
Metabolic Effects of Short-term Ultra-processed Food Intake (MEST-UPF)
Metabolic Effects of Short-term Ultra-processed Food Intake (MEST-UPF): a Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 9 Sept 2026
Brief summary (registry, in English)
The overall aim of this project is to study the effects of short-term high ultra-processed food intake, compared to nutrient- and energy density matched low ultra-processed food (UPF) intake, on energy intake and appetite. A total of 24 men and women who meet all inclusion criteria and none of the exclusion criteria will be invited to participate. A randomized 2\*2 factorial four-way crossover study will be conducted at the Department of Internal medicine and Clinical Nutrition at the University of Gothenburg, comparing a high-UPF meal to a low-UPF meal also with high and/or low energy density. A supervised breakfast meal will be served, and postprandial blood samples and appetite measures will be collected continuously up to 4 hours after the breakfast meal. Subsequently, an ad libitum lunch meal will be served, and energy intake will be recorded.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 24 (estimated)
- First submitted
- 23 Sept 2025
- Start date
- 1 Dec 2025
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Göteborg University
- Diseases
- Obesity
- NCT number
- NCT07213245
What you commit to
- Study type: Interventional
- Planned participants: 24
- From 1 Dec 2025 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Blood donation or participation in a clinical study with blood sampling within 30 days prior to screening visit and throughout the study.
- Following any weight reduction program or having followed one during the last 6 months prior to screening.
Other illness
- Food allergies, intolerances or preferences preventing consumption of any products included in the study.
- History of gastrointestinal conditions or major gastrointestinal surgery (Inflammatory bowel disease, Crohn's disease, malabsorption, colostomy, bowel resection, gastric bypass surgery etc.).
- Type 1 diabetes or type 2 diabetes.
- Thyroid disorder.
Other
- Unable to sufficiently understand written and spoken Swedish or English to provide written consent and understand information and instructions from the study personal.
- Pregnant, lactating or planning a pregnancy during the study period.
- Current smoking, vaping.
- Not habitually eating breakfast (\<5 times/week).
- Restrained eating based on the three-factor eating questionnaire.
Who the study is looking for
- Body mass index (BMI) 18.5-30 kg/m2
- Fasting glucose \< 6.1 mmol/l
- Hb \>110 g/L
- Weight stability the last 3 months +/-5%
Age in the registry: 18 years to 50 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of internal medicine and clinical nutrition, University olf Gothenburg Coordinator of this site? Confirm its status | Gothenburg | Sweden | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.