Daridorexant for Alzheimer Disease Prevention

Prior treatment

• Currently taking a DORA
• Use of benzodiazepines or z-drugs \> 2 times per week in the last month.
• Use of major and moderate CYP3A4 inducers and inhibitors
• Active use of cholinesterase inhibitors or memantine

Other illness

• Clinical diagnosis of major neurocognitive disorder
• Unstable psychiatric condition:
• Unstable medical condition in the opinion of the investigator.
• Known or suspected history of drug or alcohol dependence or abuse within one year of the screening visit
• Allergy or significant adverse reaction to DORA
• Clinically significant non-treated rapid eye movement (REM) sleep behavior disorder, restless leg syndrome or parasomnia;

Other

• Clinically significant active suicidal ideations
• Use of strong central nervous system depressants, opioids, strong analgesics, antipsychotics, sedative antidepressants.
• Women who are breast feeding or pregnant
• Severe obstructive sleep apnea (OSA)\*
• Diagnosis of narcolepsy

• Without dementia as determined by: MoCA \>21 or MMSE \> 24 or Clinical Dementia Rating \<1
• Minimum of 6 years of formal education
• Stable psychoactive medication for 1 month prior to screening with no intention to change dose during treatment period
• Capacity to provide written consent in English or French