NCT07215195Recruiting
Neuropsychiatric Outcomes and Disrupted Sleep Following Acquired Brain Injury
Source: ClinicalTrials.gov · Last updated 23 Jul 2026
Brief summary (registry, in English)
The two most common causes of brain injury are stroke and trauma. Both sleep and mental health problems are common after brain injury; we will investigate whether there is a relationship between poor sleep quality and worse mental health in this group. We will also follow patients up, at approximately three-monthly intervals until one year after injury, to see how sleep and mental health symptoms change over time and with recovery. We will assess sleep in detail using questionnaires, a sleep monitor worn on the wrist, a portable brain activity sensor, and a sleep mat. We will assess mental health (neuropsychiatric) symptoms using questionnaires. Participants will be asked to complete these assessments at baseline and at approximately 3-monthly intervals until they reach 12 months post-injury. This data will allow us to explore the types of sleep disruption seen after brain injury and examine the association between sleep and mental health symptoms.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 150 (estimated)
- First submitted
- 1 Oct 2025
- Start date
- 10 Oct 2025
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- University of Oxford
- Diseases
- Stroke
- NCT number
- NCT07215195
What you commit to
- Study type: Observational
- Planned participants: 150
- From 10 Oct 2025 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous brain injury.
Other illness
- Brain injury not caused by trauma, haemorrhage or stroke
- Other relevant neurological conditions which could affect outcome measures (e.g., Parkinson's or Alzheimer's disease)
Other
- No stable and suitable place to sleep
Who the study is looking for
- Willing and able to give informed consent for participation in the study.
- Aged 18 years or above.
- At least one week, but less than 12 months post-injury
- Clinical diagnosis of acquired brain injury (stroke, haemorrhage or traumatic).
- Participants with Traumatic Brain Injury will have a Mild (probable) or Moderate-severe (definite) brain injury according to the Mayo classification
- Participants must be willing to consent to us contacting their general practitioner (GP) or direct care team if we have concerns about their mental health
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Oxford Centre for Integrative Neuroimaging (WIN) FMRIB, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford OX3 9DU Coordinator of this site? Confirm its status | Oxford | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.