NCT07216209Recruiting
The Impact of Exercise on the Tumor Microenvironment in Patients With Lung Cancer
Exercise and the Lung Cancer Tumor Microenvironment
Source: ClinicalTrials.gov · Last updated 21 Apr 2026
Brief summary (registry, in English)
There is increased interest and knowledge about the lung cancer tumor microenvironment (TME). Investigators hypothesize that patients with better baseline physiologic health will have better post-operative outcomes and that strenuous exercise will alter the TME and genetic make-up of the tumor, improving the tumor immune response. Investigators aim to identify the peri-operative and clinical outcomes that differ based on pre-operative VO2max, HRV and resting heart rate following resection of early-stage lung cancer. The physiologic states that are individual and measurable with wearable devices include but are not limited to VO2max, heart rate variability (HRV), and average resting heart rate. Investgators hypothesize that a patient's pre-operative physiologic function with higher VO2max, HRV and lower resting heart rate will be associated with improved peri-operative and post-operative outcomes. Second, investigators will compare alterations in TME based on targeted pre-operative exercise (60-80% of their VO2 max for 75min/week x2 weeks) compared to normal activity adults following resection of early-stage lung cancer. Investigators hypothesize that strenuous exercise in the pre-operative period will impact the TME by increasing levels of cytokines.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 48 (estimated)
- First submitted
- 10 Dec 2024
- Start date
- Jan 2026
- Primary completion date
- Jan 2030
- Lead sponsor
- University of Arizona
- Diseases
- Lung cancer
- NCT number
- NCT07216209
What you commit to
- Study type: Interventional
- Planned participants: 48
- From Jan 2026 to the primary completion date, Jan 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- select a condition on the ACSM-AHA pre-exercise screening questionnaire indicating that physician approval is required prior to exercise
Other illness
- have common illness (i.e. colds) within the past 6-weeks
- HIV
- hepatitis
- history of stroke
- major affective disorder
- autoimmune disease
- history of severe anaphylactic reaction to an allergen
Age
- younger than 18 years of age
- present with more than one of the following CVD risk factors: family history of myocardial infarction, coronary revascularization, or sudden death before 55 years of age in father or other male first-degree relative or before 65 years of age in mother or other female first-degree relative
Other
- body mass index of \>30 kg/m2
- waist girth of \>102cm for men and \>88cm for women
- have chronic/debilitating arthritis
- have been bedridden in the past three months
- pregnancy or are breast-feeding
Who the study is looking for
- lung cancer
- low risk for submaximal exercise testing in accordance with the risk stratification guidelines published by the American Heart Association and the American College of Sports Medicine (AHA/ACSM criteria).
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Arizona Cancer Center Coordinator of this site? Confirm its status | Tucson | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.