NCT07218094Enrolling by invitation
Neuromechanical Mechanisms of Exosuit-assisted Gait Rehabilitation After Stroke
Source: ClinicalTrials.gov · Last updated 11 Aug 2026
Brief summary (registry, in English)
Stroke survivors often experience impaired neuromechanical control that limits walking speed and quality, particularly due to deficits in paretic propulsion. This study aims to identify patient-specific neuromechanical locomotor control strategies, link them to biomechanical gait impairments, and investigate how these strategies influence responses to soft robotic exosuit assistance of paretic propulsion and ground clearance during walking. The study focuses on adults who are more than six months post-stroke and have observable gait deficits. The main questions are: 1. How do neuromechanical control patterns (i.e., electromyography-measured muscle coordination) affect walking speed, quality, and gait biomechanics after stroke? 2. Do individuals with distinct neuromechanical patterns respond differently to robotic exosuit-assisted gait rehabilitation? Researchers will compare walking performance without and with robotic exosuit assistance to determine whether tailoring exosuit-assisted gait intervention to patient-specific neuromechanical profiles can lead to greater improvements in walking function. Participants will complete treadmill and overground walking assessments instrumented with motion capture, EMG, and force plates, performing one trial without assistance and two trials with robotic exosuit assistance delivered at different assistance onset timings, from which a preferred assistance setting will be identified. The walking trial associated with the preferred assistance setting will be used for primary analyses.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 22 (estimated)
- First submitted
- 2 Oct 2025
- Start date
- 11 Sept 2025
- Primary completion date
- Feb 2027
- Lead sponsor
- Boston University Charles River Campus
- Diseases
- Stroke
- NCT number
- NCT07218094
What you commit to
- Study type: Interventional
- Planned participants: 22
- From 11 Sept 2025 to the primary completion date, Feb 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Unexplained dizziness or more than 2 falls in the previous month
Other illness
- Comorbidities besides stroke that impair walking (musculoskeletal, cardiovascular, pulmonary, or neurological)
- Inability to wear the exosuit due to conditions that require medical management, such as open wounds or broken skin, or as assessed by a licensed physical therapist.
Other
- Severe pain, neglect, hemianopia, or aphasia limiting comprehension
- Inability to communicate (as assessed by a licensed physical therapist)
Who the study is looking for
- At least 18 years old
- \>6 months post-stroke
- Observable gait deficits
- Able to walk overground and on a treadmill without body-weight support
- Able to communicate clearly with investigators and follow instructions
- Able to fit the exosuit components, including height between 4'8" and 6'7", weight \< 264lbs, neutral ankle dorsiflexion during standing.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Boston University Neuromotor Recovery Laboratory Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.