NCT07218341RecruitingPhase 4
A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Long-Term Safety of Pirtobrutinib in Participants From Study LOXO-BTK-20020 With BTKi Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Source: ClinicalTrials.gov · Last updated 22 Sept 2026
Brief summary (registry, in English)
This study will evaluate the long-term safety of pirtobrutinib in participants with previously treated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study is open to those who completed J2N-MC-JZNN/LOXO-BTK-20020 (NCT 04666038) for continued access to the study intervention or continued follow-up visits. Treatment will be given every 4 weeks and this study is expected to last about 5 years.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- First submitted
- 16 Oct 2025
- Start date
- 9 Mar 2026
- Primary completion date
- 31 May 2030
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Chronic lymphocytic leukaemia
- NCT number
- NCT07218341
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 150
- From 9 Mar 2026 to the primary completion date, 31 May 2030
- 50 sites in 17 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- This is not applicable to this study
Who the study is looking for
- Are actively participating in study J2N-MC-JZNN/LOXO-BTK-20020
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (50)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| LKH - Universitätsklinikum der PMU Salzburg Coordinator of this site? Confirm its status | Salzburg | Austria | Not yet recruiting |
| The Alfred Hospital Coordinator of this site? Confirm its status | Melbourne | Australia | Not yet recruiting |
| AZ Delta Coordinator of this site? Confirm its status | Roeselare | Belgium | Not yet recruiting |
| Princess Margaret Cancer Centre - University Health Network Coordinator of this site? Confirm its status | Toronto | Canada | Not yet recruiting |
| Xuanwu Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Not yet recruiting |
| Hunan Cancer Hospital Coordinator of this site? Confirm its status | Changsha | China | Not yet recruiting |
| Sun Yat-Sen University Cancer Center Coordinator of this site? Confirm its status | Guangdong | China | Not yet recruiting |
| Nanfang Hospital of Southern Medical University Coordinator of this site? Confirm its status | Guangzhou | China | Recruiting |
| Gansu Provincial Cancer Hospital Coordinator of this site? Confirm its status | Lanzhou | China | Not yet recruiting |
| The First Affiliated Hospital of NanChang University Coordinator of this site? Confirm its status | Nanchang | China | Not yet recruiting |
| Fudan University Shanghai Cancer Center Coordinator of this site? Confirm its status | Shanghai | China | Not yet recruiting |
| Taizhou Hospital of Zhejiang Province Coordinator of this site? Confirm its status | Taizhou | China | Not yet recruiting |
| Hematology Hospital of the Chinese Academy of Medical Sciences Coordinator of this site? Confirm its status | Tianjin | China | Recruiting |
| Tianjin Medical University Cancer Institute & Hospital Coordinator of this site? Confirm its status | Tianjin | China | Not yet recruiting |
| Affiliated Cancer Hospital of Xinjiang Medical University Coordinator of this site? Confirm its status | Ürümqi | China | Not yet recruiting |
| The Affiliated Hospital of Xuzhou Medical College Coordinator of this site? Confirm its status | Xuzhou | China | Not yet recruiting |
| Henan Cancer Hospital Coordinator of this site? Confirm its status | Zhengzhou | China | Not yet recruiting |
| Fakultni nemocnice Hradec Kralove Coordinator of this site? Confirm its status | Hradec Králové | Czechia | Not yet recruiting |
| Hospital Universitario Marqués de Valdecilla Coordinator of this site? Confirm its status | Santander | Spain | Not yet recruiting |
| Hospital Universitario Virgen del Rocio Coordinator of this site? Confirm its status | Seville | Spain | Not yet recruiting |
| Centre Henri Becquerel Coordinator of this site? Confirm its status | Rouen | France | Not yet recruiting |
| Castle Hill Hospital Coordinator of this site? Confirm its status | Hull | United Kingdom | Not yet recruiting |
| St James's University Hospital Coordinator of this site? Confirm its status | Leeds | United Kingdom | Recruiting |
| GenesisCare Coordinator of this site? Confirm its status | Newmarket | United Kingdom | Not yet recruiting |
| University Hospital Center Zagreb Coordinator of this site? Confirm its status | Zagreb | Croatia | Not yet recruiting |
| Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet Coordinator of this site? Confirm its status | Budapest | Hungary | Not yet recruiting |
| Debreceni Egyetem Coordinator of this site? Confirm its status | Debrecen | Hungary | Not yet recruiting |
| St. James's Hospital Coordinator of this site? Confirm its status | Dublin | Ireland | Not yet recruiting |
| Beaumont Hospital Coordinator of this site? Confirm its status | Dublin | Ireland | Not yet recruiting |
| Tel-Aviv Sourasky Medical Center Coordinator of this site? Confirm its status | Tel Aviv | Israel | Not yet recruiting |
| Azienda Ospedaliero - Universitaria Nazionale Santi Antonio e Biagio e Cesare Arrigo Coordinator of this site? Confirm its status | Alessandria | Italy | Not yet recruiting |
| Azienda Ospedaliera Universitaria Careggi Coordinator of this site? Confirm its status | Florence | Italy | Not yet recruiting |
| Presidio Ospedaliero Papardo Coordinator of this site? Confirm its status | Messina | Italy | Not yet recruiting |
| Fondazione IRCCS San Gerardo dei Tintori Coordinator of this site? Confirm its status | Monza | Italy | Not yet recruiting |
| Azienda Ospedaliera di Perugia;Ospedale S. Maria della Misericordia Coordinator of this site? Confirm its status | Perugia | Italy | Not yet recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Not yet recruiting |
| Azienda Ospedaliera S Maria Di Terni Coordinator of this site? Confirm its status | Terni | Italy | Not yet recruiting |
| Tokai University Hospital Coordinator of this site? Confirm its status | Isehara | Japan | Recruiting |
| Szpital Specjalistyczny W Brzozowie Podkarpacki Osrodek Onkologiczny Im.Ks.B.Markiewicza Coordinator of this site? Confirm its status | Brzozów | Poland | Not yet recruiting |
| Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Not yet recruiting |
| Pratia Onkologia Katowice Coordinator of this site? Confirm its status | Katowice | Poland | Not yet recruiting |
| Oncology Hematology Care, Inc Coordinator of this site? Confirm its status | Cincinnati | United States | Not yet recruiting |
| Minnesota Oncology Hematology, P.A. Coordinator of this site? Confirm its status | Coon Rapids | United States | Recruiting |
| Texas Oncology Paris Coordinator of this site? Confirm its status | Fort Worth | United States | Not yet recruiting |
| Cayuga Cancer Center Coordinator of this site? Confirm its status | Ithaca | United States | Not yet recruiting |
| Cancer Specialists, LLC Coordinator of this site? Confirm its status | Jacksonville | United States | Recruiting |
| US Oncology - Texas Oncology Coordinator of this site? Confirm its status | Kyle | United States | Not yet recruiting |
| Mitchell Cancer Institute Coordinator of this site? Confirm its status | Mobile | United States | Recruiting |
| Memorial Sloan-Kettering Cancer Center (Mskcc) - New York Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Arizona Oncology Associates, P.C. - HOPE Coordinator of this site? Confirm its status | Tucson | United States | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.