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NCT07219212RecruitingPhase 1

A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma

A Study of JNJ-90301900 in Combination With Concurrent Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma

Source: ClinicalTrials.gov · Last updated 3 Nov 2026

Brief summary (registry, in English)

This global, open-label, single arm, phase 1b study aims to learn more about whether a treatment called JNJ-90301900 is safe and effective when injected directly into tumors, along with standard chemotherapy and radiation therapy, for participants with head and neck squamous cell cancer (HNSCC; a type of solid tumor that begins in outer tissue layer of the mouth \& throat).

Status (registry)
Recruiting
Phase (registry)
Phase 1
Study type
Interventional
Enrollment
45 (estimated)
First submitted
17 Oct 2025
Start date
26 Jan 2026
Primary completion date
14 Jul 2028
Lead sponsor
Johnson & Johnson Enterprise Innovation Inc.
NCT number
NCT07219212
EU CT number
2025-522914-22-00

What you commit to

  • Study type: Interventional · Phase 1
  • Planned participants: 45
  • From 26 Jan 2026 to the primary completion date, 14 Jul 2028
  • 25 sites in 4 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Ineligible to receive platinum-based chemotherapy

Other illness

  • Suspected or known allergies, hypersensitivity, or intolerance to JNJ-90301900 or its excipients

Other

  • Primary tumor originating in the nasopharynx, paranasal sinuses, salivary glands, thyroid gland, parathyroid gland, skin, or unknown primary site
  • Non-squamous histology
  • Stages 0, I, II, and IVC HNSCC, loco-regionally recurrent HNSCC, or synchronous second primary HNSCC (within 2 months)

Who the study is looking for

  • Pathologically (histologically or cytologically) proven diagnosis of HNSCC of the oral cavity, oropharynx (p16 negative), hypopharynx, or supraglottic larynx
  • Stage III, IVA or IVB according to the 8th Edition of the American Joint Committee on Cancer (AJCC) guidelines
  • A candidate for definitive concurrent chemoradiation therapy treatment as determined by investigator and per local guidelines
  • Participants must have at least 1 target lesion (primary tumor or involved lymph node) per RECIST v.1.1
  • Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0 or 1

Age in the registry: 18 years to 74 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (25)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Institut Catala D'oncologia
Coordinator of this site? Confirm its status
L'Hospitalet de LlobregatSpainRecruiting
Hospital Universitario Fundación Jiménez Díaz
Coordinator of this site? Confirm its status
MadridSpainRecruiting
Hospital General Universitario Gregorio Marañón
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MadridSpainRecruiting
Hospital Universitario Y Politecnico La Fe
Coordinator of this site? Confirm its status
ValenciaSpainRecruiting
Centre Hospitalier Régional et Universitaire de Brest
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BrestFranceRecruiting
Centre Hospitalier Universitaire Grenoble Alpes
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Grenoble Cedex 9FranceRecruiting
Centre Oscar Lambret
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LilleFranceRecruiting
Centre Hospitalier Regional De Marseille
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MarseilleFranceRecruiting
Centre Henri Becquerel
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Rouen CedexFranceRecruiting
Institut Gustave Roussy
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VillejuifFranceRecruiting
Hiroshima University Hospital
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HiroshimaJapanRecruiting
National Cancer Center Hospital East
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KashiwaJapanRecruiting
Aichi Cancer Center
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NagoyaJapanRecruiting
Shizuoka Cancer Center
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ShizuokaJapanRecruiting
Tokyo Medical University Hospital
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TokyoJapanRecruiting
Emory University
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AtlantaUnited StatesRecruiting
University of Alabama at Birmingham
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BirminghamUnited StatesRecruiting
Boston Medical Center
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BostonUnited StatesRecruiting
University of North Carolina at Chapel Hill
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Chapel HillUnited StatesRecruiting
City of Hope
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DuarteUnited StatesRecruiting
Mayo Clinic
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JacksonvilleUnited StatesRecruiting
University of California at San Diego - Moores Cancer Center
Coordinator of this site? Confirm its status
La JollaUnited StatesSuspended
University of Pennsylvania
Coordinator of this site? Confirm its status
PhiladelphiaUnited StatesRecruiting
Moffit Cancer Center
Coordinator of this site? Confirm its status
TampaUnited StatesRecruiting
Montefiore Medical Center
Coordinator of this site? Confirm its status
The BronxUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.