NCT07220642Active, not recruitingPhase 3
Weight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide
Efficacy and Safety of Cagrilintide for Weight Management in Participants With Overweight or Obesity
Source: ClinicalTrials.gov · Last updated 6 Aug 2026
Brief summary (registry, in English)
This study will look at how much cagrilintide helps people with overweight or obesity lower their body weight. Cagrilintide is a new investigational medicine. Doctors may not yet prescribe cagrilintide. Participants will either get cagrilintide or placebo. Which treatment participants get is decided by chance. Participants are two times more likely to get cagrilintide than placebo. Like all medicines, the study medicine may have side effects. Possible side effects will be followed carefully during the study. For each participant, the study will last for about 1 year and 6 months.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 300 (estimated)
- First submitted
- 23 Oct 2025
- Start date
- 5 Nov 2025
- Primary completion date
- 11 May 2027
- Lead sponsor
- Novo Nordisk A/S
- Diseases
- Obesity
- NCT number
- NCT07220642
- EU CT number
- 2024-519530-24-00
- EudraCT number
- 2024-519530-24
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 300
- From 5 Nov 2025 to the primary completion date, 11 May 2027
- 39 sites in 10 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment, or intention to initiate treatment, with any medication prescribed for the indication of weight management within 180 days before screening (a\*)
- Previous dosing of marketed or non-marketed amylin-based compounds (a\*) (a\*) - As declared by the participant, reported in the medical records or at the investigator's discretion.
Other illness
- History of type 1 or type 2 diabetes (a\*)
Who the study is looking for
- Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study
- Female or male (sex at birth)
- Age 18 years or above at the time of signing the informed consent
- History of at least one self-reported unsuccessful dietary effort to lose body weight (a\*)
- Body mass index (BMI) greater than or equal to \>= 30.0 kilogram per square meter (kg/m\^2), or BMI greater than or equal to \>= 27.0 kg/m\^2 with the presence of at least one weight related comorbidity including, but not limited to, hypertension, dyslipidaemia, obstructive sleep apnoea or cardiovascular disease (a\*)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (39)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CIPREC Pueyrredon Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Cedic - Centro de Investigacion Clinica Coordinator of this site? Confirm its status | CABA | Argentina | Unknown status |
| Sydney Cardiometabolic Centre Coordinator of this site? Confirm its status | Liverpool | Australia | Unknown status |
| Hunter Diabetes Centre Coordinator of this site? Confirm its status | Merewether | Australia | Unknown status |
| Nova Scotia Hlth Halifax Coordinator of this site? Confirm its status | Halifax | Canada | Unknown status |
| Hamilton Medical Research Group Coordinator of this site? Confirm its status | Hamilton | Canada | Unknown status |
| Wharton Medical Clinic Clinical Trials (Hamilton) Coordinator of this site? Confirm its status | Hamilton | Canada | Unknown status |
| Milestone Research Coordinator of this site? Confirm its status | London | Canada | Unknown status |
| Centricity Research Mirabel Coordinator of this site? Confirm its status | Mirabel | Canada | Unknown status |
| G.A. Research Associates, Ltd. Coordinator of this site? Confirm its status | Moncton | Canada | Unknown status |
| Centricity Research Oshawa Coordinator of this site? Confirm its status | Oshawa | Canada | Unknown status |
| Centricity Research Toronto Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| InnoDiab Forschung Gmbh Coordinator of this site? Confirm its status | Essen | Germany | Active, not recruiting |
| Gemeinschaftspraxis für Innere Medizin, Diabetologie und Endokrinologie Coordinator of this site? Confirm its status | Hamburg | Germany | Active, not recruiting |
| R.E.D. Institut fuer medizinische Studien und Fortbildung GmbH Coordinator of this site? Confirm its status | Oldenburg in Holstein | Germany | Active, not recruiting |
| Centre Hospitalier Universitaire de Nantes Coordinator of this site? Confirm its status | Saint-Herblain | France | Active, not recruiting |
| Centre de Recherche Clinique Portes Du Sud Coordinator of this site? Confirm its status | Vénissieux | France | Active, not recruiting |
| Oak Tree Surgery Coordinator of this site? Confirm its status | Liskeard | United Kingdom | Unknown status |
| North Coast Medical Ltd Coordinator of this site? Confirm its status | Newquay | United Kingdom | Unknown status |
| Brunel Medical Practice Coordinator of this site? Confirm its status | Torquay | United Kingdom | Unknown status |
| Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico Coordinator of this site? Confirm its status | Bologna | Italy | Active, not recruiting |
| Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Coordinator of this site? Confirm its status | Palermo | Italy | Active, not recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Active, not recruiting |
| Helse Bergen HF Coordinator of this site? Confirm its status | Bergen | Norway | Active, not recruiting |
| Drammen Sykehus Coordinator of this site? Confirm its status | Drammen | Norway | Active, not recruiting |
| St. Olavs hospital HF Coordinator of this site? Confirm its status | Trondheim | Norway | Active, not recruiting |
| Osteo-Medic s.c. A. Racewicz, J. Supronik Coordinator of this site? Confirm its status | Bialystok | Poland | Active, not recruiting |
| Care Clinic Sp. Z O.O. Coordinator of this site? Confirm its status | Katowice | Poland | Active, not recruiting |
| Terpa Sp. z o.o. Sp. k. Coordinator of this site? Confirm its status | Lublin | Poland | Active, not recruiting |
| Nbr Polska Tomasz Klodawski Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Univ of Colorado at Denver Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| StudyMetrix Research, LLC Coordinator of this site? Confirm its status | City of Saint Peters | United States | Unknown status |
| PharmQuest Life Sciences LLC Coordinator of this site? Confirm its status | Greensboro | United States | Unknown status |
| Midwest Inst For Clin Res Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| Walgreens - Store 11760 Coordinator of this site? Confirm its status | Oak Park | United States | Unknown status |
| Florida Inst For Clin Res LLC Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Oviedo Medical Research, LLC Coordinator of this site? Confirm its status | Oviedo | United States | Unknown status |
| Diablo Clinical Research, Inc. Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| Selma Medical Associates Coordinator of this site? Confirm its status | Winchester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.