NCT07223697Active, not recruitingPhase 2
A Long Term Extension Study to Evaluate the Safety and Efficacy of Afimkibart (RO7790121) in Participants With Atopic Dermatitis
An Extension Study To Evaluate the Long-Term Safety and Efficacy of Afimkibart (RO7790121) in Patients With Atopic Dermatitis Who Participated in Previous Afimkibart Clinical Trials
Source: ClinicalTrials.gov · Last updated 26 Oct 2026
Brief summary (registry, in English)
This study will assess long-term safety and efficacy of Afimkibart (also known as RO7790121) in participants with Atopic Dermatitis (AD) who participated in previous afimkibart clinical trials.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 30 Oct 2025
- Start date
- 8 Jan 2026
- Primary completion date
- 1 Mar 2033
- Lead sponsor
- Hoffmann-La Roche
- Diseases
- Atopic dermatitis (eczema)
- NCT number
- NCT07223697
- EU CT number
- 2025-520771-59-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 120
- From 8 Jan 2026 to the primary completion date, 1 Mar 2033
- 48 sites in 8 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any permanent discontinuation of study drug in parent study
Other illness
- Evidence of other skin conditions that would interfere with the assessment of AD
- History of severe allergic reaction or anaphylactic reaction to any biologic agent or known hypersensitivity to any component of Afimkibart
Other
- Withdrawal of consent and/or premature discontinuation from parent study
Who the study is looking for
- Ability and willingness to comply with all aspects of the protocol including completion of the efficacy assessments (EASI and IGA), clinical outcome assessment instruments (DLQI, POEM), and safety and PK sample collections for the duration of the study
- Parent Clinical Trial-Specific Criteria:
- Study CS45570 participants who continued to be evaluated at the Week 36 follow up visit and achieved =\> EASI50 response from study baseline
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (48)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Unesp - Faculdade de Medicina Da Universidade Estadual Paulista - Campus Botucatu Coordinator of this site? Confirm its status | Botucatu | Brazil | Unknown status |
| Centro de Pesquisa Sao Lucas Coordinator of this site? Confirm its status | Campinas | Brazil | Unknown status |
| Centro de Estudos em Terapias Inovadoras ? CETI Coordinator of this site? Confirm its status | Curitiba | Brazil | Unknown status |
| Irmandade Da Santa Casa de Misericordia de Porto Alegre Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Hospital de Clnicas de Porto Alegre Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Instituto Brasil de Pesquisa Clínica-IBPCLIN S/A Coordinator of this site? Confirm its status | Rio de Janeiro | Brazil | Unknown status |
| HMCG - Hospital e Maternidade Dr. Christovo da Gama Coordinator of this site? Confirm its status | Santo Andr | Brazil | Unknown status |
| Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto Hospital de Base - PPDS Coordinator of this site? Confirm its status | Sao Jose Rio Preto | Brazil | Unknown status |
| Dermeffects Coordinator of this site? Confirm its status | London | Canada | Unknown status |
| Lynderm Research Inc. Coordinator of this site? Confirm its status | Markham | Canada | Unknown status |
| DermEdge Research Coordinator of this site? Confirm its status | Mississauga | Canada | Unknown status |
| Ryan Clinical Research Inc Coordinator of this site? Confirm its status | Newmarket | Canada | Unknown status |
| Thermalsole und Schwefelbad Bentheim GmbH Coordinator of this site? Confirm its status | Bad Bentheim | Germany | Recruiting |
| Deutsches Rotes Kreuz Gemeinnuetzige Krankenhaus GmbH Sachsen Coordinator of this site? Confirm its status | Chemnitz | Germany | Recruiting |
| Medical Center- University of Freiburg Coordinator of this site? Confirm its status | Freiburg im Breisgau | Germany | Recruiting |
| Dermatologikum Hamburg Gmbh Coordinator of this site? Confirm its status | Hamburg | Germany | Recruiting |
| Harzklinikum Dorothea Christiane Erxleben GmbH Coordinator of this site? Confirm its status | Quedlinburg | Germany | Recruiting |
| Hospital de la Santa Creu i Sant Pau Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Hospital Universitario Reina Sofia Coordinator of this site? Confirm its status | Córdoba | Spain | Active, not recruiting |
| Clinica Universidad de Navarra Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital Universitario La Paz Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Clínica Universidad de navarra Coordinator of this site? Confirm its status | Pamplona | Spain | Active, not recruiting |
| Complexo Hospitalario Universitario De Santiago Coordinator of this site? Confirm its status | Santiago de Compostela | Spain | Active, not recruiting |
| Assistance Publique Hopitaux de Paris Coordinator of this site? Confirm its status | Paris | France | Not yet recruiting |
| Centre Hospitalier Universitaire Rouen Coordinator of this site? Confirm its status | Rouen Cedex | France | Not yet recruiting |
| Azienda Ospedaliero-Universitaria delle Marche Coordinator of this site? Confirm its status | Ancona | Italy | Recruiting |
| Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco Di Catania Coordinator of this site? Confirm its status | Catania | Italy | Recruiting |
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Recruiting |
| Centrum Nowoczesnych Terapii Dobry Lekarz Sp. z o.o. Coordinator of this site? Confirm its status | Cracow | Poland | Recruiting |
| Pratia S.A. Coordinator of this site? Confirm its status | Gdynia | Poland | Recruiting |
| Pratia S.A. Coordinator of this site? Confirm its status | Katowice | Poland | Recruiting |
| Specjalistyczny Gabinet Dermatologiczny Aplikacyjno Badawczy Marek Brzewski Paweł Brzewski s.c. Coordinator of this site? Confirm its status | Krakow | Poland | Recruiting |
| Dermoklinika Centrum Medyczne s.c. M. Kierstan, J. Narbutt, A. Lesiak Coordinator of this site? Confirm its status | Łódź | Poland | Recruiting |
| Uniwersytecki Szpital Kliniczny Im. Fryderyka Chopina W Rzeszowie Coordinator of this site? Confirm its status | Rzeszów | Poland | Recruiting |
| Laser Clinic S.C. dr Tomasz Kochanowski dr Andrzej Królicki Coordinator of this site? Confirm its status | Szczecin | Poland | Recruiting |
| Medicover Integrated Clinical Services Sp. z o.o. Coordinator of this site? Confirm its status | Torun | Poland | Recruiting |
| Medicover Integrated Clinical Services Sp. z o.o. Coordinator of this site? Confirm its status | Warsaw | Poland | Recruiting |
| Klinika Ambroziak Sp. z o.o. Coordinator of this site? Confirm its status | Warsaw | Poland | Recruiting |
| Medical Network Sp z o o Coordinator of this site? Confirm its status | Warsaw | Poland | Recruiting |
| ROYALDERM AGNIESZKA NAWROCKA Coordinator of this site? Confirm its status | Warszawa | Poland | Recruiting |
| Hamilton Research LLC Coordinator of this site? Confirm its status | Alpharetta | United States | Unknown status |
| Best Skin Research, LLC Coordinator of this site? Confirm its status | Camp Hill | United States | Unknown status |
| Dermatology Research Associate Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| UCLA Division of Dermatology Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| University of Minnesota Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Olympian Clinical Research Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Revival Research Institute, LLC Coordinator of this site? Confirm its status | Troy | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.