NCT07224243Recruiting
Impact of Intraoperative Oxygenation Practices on Patient Outcomes
Source: ClinicalTrials.gov · Last updated 16 Sept 2026
Brief summary (registry, in English)
This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80), and higher (FiO₂ 0.80-1.00)-on postoperative organ injury and mortality in adult surgical patients. The trial aims to determine the optimal oxygenation strategy to improve perioperative outcomes.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 54000 (estimated)
- First submitted
- 31 Oct 2025
- Start date
- 1 Dec 2025
- Primary completion date
- 29 Feb 2028
- Lead sponsor
- Frederic T Billings IV
- Diseases
- Stroke
- NCT number
- NCT07224243
What you commit to
- Study type: Interventional
- Planned participants: 54000
- From 1 Dec 2025 to the primary completion date, 29 Feb 2028
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patient's planned procedure requires prolonged apnea, bronchoscopy, airway surgery, or one-lung ventilation.
- Patient's planned surgical case includes use of extracorporeal membrane oxygenation (ECMO).
- Patient was enrolled in the trial in the prior 30 days.
Other illness
- Patient's planned surgical case includes open heart surgery, defined as surgery on the heart or ascending aorta requiring sternotomy or thoracotomy.
- Patient is known to have a history of bleomycin treatment.
Age
- Patient is known to be less than 18 years old
Other
- Patient is known to be pregnant
- Patient is known to be a prisoner.
- Patient is American Society of Anesthesiologists (ASA) classification-6 (i.e., organ donor)
Who the study is looking for
- Patient located in a participating operating room
- Planned surgery includes tracheal intubation
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Michigan Hospital Coordinator of this site? Confirm its status | Ann Arbor | United States | Recruiting |
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
| Nebraska Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Recruiting |
| University of Utah - Huntsman Cancer Institute Coordinator of this site? Confirm its status | Salt Lake City | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.