NCT07224347Active, not recruiting
Aspirin in Reducing Events in the Elderly-Extension (ASPREE-XT)
Source: ClinicalTrials.gov · Last updated 4 Nov 2025
Brief summary (registry, in English)
ASPREE-XT is a post-treatment, longitudinal observational follow-up study of ASPREE participants. Although the ASPREE trial medication was ceased, the study activity was not stopped and ASPREE participants are continuing with scheduled visits and phone calls. An observational follow-up phase (ASPREE-XT), began in January, 2018. This will enable the monitoring of possible delayed effects of aspirin treatment, primarily on cancer incidence, metastases and mortality. In addition to monitoring the incidence of malignancy within the ASPREE cohort, the opportunity will be taken to observe any other residual effects of aspirin on the endpoints being monitored in the cohort. Continuity of contact with study participants is the key to retention of the cohort for any ongoing or future studies.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 19114 (actual)
- First submitted
- 31 Oct 2025
- Start date
- 15 Jul 2019
- Primary completion date
- 30 Apr 2026
- Lead sponsor
- Anne Murray
- Diseases
- Stroke
- NCT number
- NCT07224347
What you commit to
- Study type: Observational
- Participants enrolled: 19114
- From 15 Jul 2019 to the primary completion date, 30 Apr 2026
- 36 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- A history of a diagnosed cardiovascular event
- A serious intercurrent illness likely to cause death within the next 5 years, such as terminal cancer or obstructive airways disease
- A current or recurrent condition with a high risk of major bleeding, ex: cerebral aneurysm
- Absolute contraindication or allergy to aspirin
- A history of dementia
Lab values
- Current continuous use of aspirin or other anti-platelet drug or anticoagulant for secondary prevention. People with previous use of aspirin for primary prevention may enter the trial, provided they agree to cease existing use of aspirin and understand that they may be subsequently randomly allocated to low dose aspirin or placebo.
Other
- Anemia
- Current participation in a clinical trial
- A systolic blood pressure ≥180 mmHg and / or a diastolic blood pressure ≥105 mmHg
- Severe difficulty or an inability to perform any one of the 6 Katz ADLs
- Non-compliance to taking pill
Who the study is looking for
- Men and women
- African American and Hispanic persons age 65 or older
- Any person from another ethnic minority group and Caucasian persons age 70 or older
- Willing and able to provide informed consent, and willing to accept the study requirements
Age in the registry: 65 years to - · Sex: All · Accepts healthy volunteers
Sites (36)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Discipline of General Practice, School of Population Health, University of Adelaide Coordinator of this site? Confirm its status | Adelaide | Australia | Unknown status |
| Bendigo Regional Clinical School Coordinator of this site? Confirm its status | Bendigo | Australia | Unknown status |
| University of Tasmania Rural Clinical School Coordinator of this site? Confirm its status | Burnie | Australia | Unknown status |
| Clinical Trials Unit, The Canberra Hospital Coordinator of this site? Confirm its status | Garran | Australia | Unknown status |
| Geelong Hospital Coordinator of this site? Confirm its status | Geelong | Australia | Unknown status |
| The Menzies Institute for Medical Research, University of Tasmania Coordinator of this site? Confirm its status | Hobart | Australia | Unknown status |
| University of Tasmania Newnham Campus Coordinator of this site? Confirm its status | Launceston | Australia | Unknown status |
| Monash Mildura Regional Clinical School Coordinator of this site? Confirm its status | Mildura | Australia | Unknown status |
| Greater Green Triangle University Coordinator of this site? Confirm its status | Mount Gambier | Australia | Unknown status |
| University of Ballarat Coordinator of this site? Confirm its status | Mount Helen | Australia | Unknown status |
| Monash Gippsland Regional Clinical School Coordinator of this site? Confirm its status | Traralgon | Australia | Unknown status |
| The South West Alliance of Rural Health (SWARH) Coordinator of this site? Confirm its status | Warrnambool | Australia | Unknown status |
| Gateway Community Health Coordinator of this site? Confirm its status | Wodonga | Australia | Unknown status |
| Illawarra Health and Medical Research Institute, University of Wollongong Coordinator of this site? Confirm its status | Wollongong | Australia | Unknown status |
| University of Michigan Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Morehouse School of Medicine Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Emory/ Atlanta VAMC Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Pennington Biomedical Research Center Coordinator of this site? Confirm its status | Baton Rouge | United States | Unknown status |
| The University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Rush Alzheimer's Disease Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| University of Texas Southwestern Medical Center at Dallas Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Wayne State University Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| University of Texas Medical Branch Coordinator of this site? Confirm its status | Galveston | United States | Unknown status |
| Wake Forest University Baptist Medical Center Coordinator of this site? Confirm its status | Greensboro | United States | Unknown status |
| The Brody School of Medicine at East Carolina University Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Regional Academic Health Center Coordinator of this site? Confirm its status | Harlingen | United States | Unknown status |
| University of Iowa Coordinator of this site? Confirm its status | Iowa City | United States | Unknown status |
| University of Tennessee Health Science Center Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| HealthPartners Research Institute Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Kent County Memorial Hospital Coordinator of this site? Confirm its status | Pawtucket | United States | Unknown status |
| Einstein Medical Center Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| University of Pittsburgh Health Sciences Research Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Phalen Village Clinic Coordinator of this site? Confirm its status | Saint Paul | United States | Unknown status |
| Ut Health Science Center At San Antonio Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| LSU Health Sciences- Shreveport Coordinator of this site? Confirm its status | Shreveport | United States | Unknown status |
| Howard University Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.