NCT07224490RecruitingPhase 1
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
Source: ClinicalTrials.gov · Last updated 13 Jul 2026
Brief summary (registry, in English)
The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome. The study subjects will receive a single bolus of kisspeptin.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 3 Nov 2025
- Start date
- 10 Mar 2026
- Primary completion date
- 31 May 2030
- Lead sponsor
- Stephanie B. Seminara, MD
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT07224490
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 40
- From 10 Mar 2026 to the primary completion date, 31 May 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Active use of illicit drugs (not including marijuana)
- Surgical or natural menopause
Other illness
- Any condition (medical, mental, or behavioral) that, in the opinion of a study investigator, would likely interfere with participation in/completion of the protocol or the interpretation of results
Other
- For women,
- Pregnant
- Trying to become pregnant during protocol participation
- Breast feeding
Who the study is looking for
- Female (ages 18-45 years) or Male (ages 18-60 years)
- No current or recent use of a medication (including hormonal replacement) that, in the opinion of a study investigator, can modulate the reproductive axis or willing to complete an appropriate washout for that particular medication and its method of administration
- For women, negative serum hCG pregnancy test
- For cases, diagnosis of post-covid-19 syndrome
- For controls, history of prior covid infection but no diagnosis of post-covid-19 syndrome
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.