NCT07224737Completed
Liquid Biopsy Using Exosomal miRNA Enables Risk Stratification of Potential Metastasis in Patients With Intrahepatic Cholangiocarcinoma.
Machine Learning-based Exosome Liquid Biopsy Enables Stratification of Occult Metastasis Risk in Patients With Intrahepatic Cholangiocarcinoma
Source: ClinicalTrials.gov · Last updated 13 Mar 2026
Brief summary (registry, in English)
Occult metastasis at the time of surgery is a major driver of poor outcomes in intrahepatic cholangiocarcinoma (ICC), yet reliable preoperative biomarkers to identify such patients are lacking. The EXOMIC study aims to develop and validate a circulating exosomal microRNA (exo-miRNA)-based liquid biopsy assay to detect occult metastasis preoperatively in patients with resectable ICC.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 230 (actual)
- First submitted
- 3 Nov 2025
- Start date
- 21 Jun 2024
- Primary completion date
- 18 Jan 2026
- Lead sponsor
- City of Hope Medical Center
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT07224737
What you commit to
- Study type: Observational
- Participants enrolled: 230
- From 21 Jun 2024 to the primary completion date, 18 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Extrahepatic cholangiocarcinoma or gallbladder cancer.
- Synchronous non-ICC malignancy.
Other
- Inadequate clinical follow-up.
- Inability to consent.
Who the study is looking for
- Histologically confirmed ICC (clinical stage I-III).
- Undergoing curative-intent hepatectomy.
- Availability of preoperative pasma or serum sample (≥200 µL).
- Standard staging imaging completed per institutional protocol.
- Written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| City of Hope Medical Center Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.