NCT07225452Completed
An Exosomal miRNA-based Liquid Biopsy for ICC Detection
Liquid Biopsy Using Exosomal miRNA for Intrahepatic Cholangiocarcinoma Detection
Source: ClinicalTrials.gov · Last updated 13 Mar 2026
Brief summary (registry, in English)
Intrahepatic cholangiocarcinoma (ICC) is a malignant liver tumor with poor prognosis and limited curative treatment options. Early and accurate detection remains an unmet clinical need. The LUMIC study aims to develop a non-invasive liquid biopsy platform based on both exosomal microRNAs (exo-miRNAs) to detect intrahepatic cholangiocarcinoma with high sensitivity and specificity.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 535 (actual)
- First submitted
- 4 Nov 2025
- Start date
- 21 Jun 2024
- Primary completion date
- 5 Jan 2026
- Lead sponsor
- City of Hope Medical Center
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT07225452
What you commit to
- Study type: Observational
- Participants enrolled: 535
- From 21 Jun 2024 to the primary completion date, 5 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of other malignancy within 5 years
- Active infection, autoimmune disease, or pregnancy
Other
- Extrahepatic cholangiocarcinoma
- Inadequate clinical data or poor sample quality
Who the study is looking for
- Age ≥ 18 years
- Histologically confirmed intrahepatic cholangiocarcinoma
- Availability of pre-treatment plasma sample
- Informed consent provided
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| City of Hope Medical Center Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.