NCT07226154Recruiting
Prediction of Neoadjuvant Chemotherapy Response in Pancreatic Cancer
An Exosomal miRNA Based Predictive Model for Personalized Neoadjuvant Chemotherapy Selection in Pancreatic Ductal Adenocarcinoma
Source: ClinicalTrials.gov · Last updated 19 Aug 2026
Brief summary (registry, in English)
This study aims to develop and validate a predictive microRNA (miRNA) panel to assess the response to neoadjuvant chemotherapy (NACT) in patients with resectable and borderline resectable pancreatic ductal adenocarcinoma (PDAC).
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 3 Nov 2025
- Start date
- 15 Nov 2024
- Primary completion date
- 1 Dec 2026
- Lead sponsor
- City of Hope Medical Center
- Diseases
- Pancreatic cancer
- NCT number
- NCT07226154
What you commit to
- Study type: Observational
- Planned participants: 200
- From 15 Nov 2024 to the primary completion date, 1 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receipt of chemotherapy regimens other than standard FOLFIRINOX or gemcitabine plus nab-paclitaxel (GEM-NABP).
Other illness
- Presence of synchronous or multiple primary malignancies.
- Presence of active inflammatory or autoimmune diseases.
Other
- Inadequate plasma samples or poor RNA quality for exosomal miRNA analysis.
- Non-adenocarcinoma histology.
Who the study is looking for
- Histologically confirmed pancreatic ductal adenocarcinoma (PDAC).
- Underwent neoadjuvant chemotherapy (FOLFIRINOX or Gemcitabine/nab-paclitaxel).
- Availability of pre-treatment plasma samples.
- Underwent curative-intent resection (R0 or R1).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| City of Hope Medical Center Coordinator of this site? Confirm its status | Duarte | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.