NCT07226518Not yet recruiting
Walking and tSCS in Non-ambulatory Stroke Survivors
Robot-assisted Gait Training and Transcutaneous Spinal Cord Stimulation in Chronic Non-ambulatory Stroke Survivors: Pilot RCT Trial
Source: ClinicalTrials.gov · Last updated 10 Nov 2025
Brief summary (registry, in English)
Rehabilitation interventions commonly used for stroke survivors include task-specific training, balance and strength exercises, and the use of assistive devices to enhance mobility and independence. Advanced technologies, such as body-weight-supported treadmill systems and robotic devices, may be employed when appropriate. Current rehabilitation therapies for stroke survivors are moderately effective with a limited effect size, especially in stroke survivors with severe impairment. Novel therapies, such as transcutaneous spinal cord stimulation (tSCS), may further improve outcomes in the target population. This pilot study will allow us to examine the feasibility and gather pilot data on a combined intervention of assistive gait training and tSCS in non-ambulatory stroke survivors.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 4 Nov 2025
- Start date
- 1 Jan 2026
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- University of Kansas Medical Center
- Diseases
- Stroke
- NCT number
- NCT07226518
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 1 Jan 2026 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Hospitalization for cardiac or pulmonary disease within the past 3 months
- Have musculoskeletal disorders that prevent the participant from participating in the exercise
- Significant ataxia or unilateral spatial neglect (score of 2 on NIH stroke scale item 7 or 11)
- Diagnosis of other neurological diseases (multiple sclerosis, Alzheimer's disease, Parkinson's disease)
Lab values
- Unable to speak or understand English, and travel to the research laboratory.
Other
- Blood pressure higher than 200/110 mm Hg
- Reported pain that limits or interferes with activities of daily living and physical activity/exercise
- Diagnosis of severe depression (HADS score 15-21)
- Contraindications to tSCS and TMS
Who the study is looking for
- Age 18-80 years at time of consent
- All genders included.
- Chronic ischemic or hemorrhagic stroke \>=6 months, with limited within-home comfortable walking speed \<= 0.49 m/s and unable to walk independently in community (FAC \<= 3)
- Able to communicate with investigators, follow 2-step command, and correctly answer consent comprehension questions in English.
- Currently not participating in treadmill walking exercises or exercises involving weight-bearing activities.
- Have physicians' approval for exercise and be in a stable medical condition
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Neuromuscular Research Laboratory Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.