NCT07226843RecruitingPhase 1
A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers
NOVA-BCL6-1, A First-in-Human, Multicenter Phase 1a/1b Study to Investigate Safety, Tolerability, Pharmacokinetics, and Efficacy of LY4584180 in Adult Participants With Previously Treated Hematologic Malignancies
Source: ClinicalTrials.gov · Last updated 4 Nov 2026
Brief summary (registry, in English)
The main purpose of this study is to evaluate safety and efficacy, and measure how much LY4584180 gets into the bloodstream and how long it takes the body to eliminate it in patients with previously treated blood cancers. For each participant, the study could last about 9 months or possibly longer including screening.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 460 (estimated)
- First submitted
- 7 Nov 2025
- Start date
- 17 Apr 2026
- Primary completion date
- Sept 2028
- Lead sponsor
- Eli Lilly and Company
- NCT number
- NCT07226843
- EU CT number
- 2025-523601-16-00
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 460
- From 17 Apr 2026 to the primary completion date, Sept 2028
- 45 sites in 8 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Has known central nervous system (CNS) involvement by systemic lymphoma. Patients with previous treatment for CNS involvement who are neurologically stable and without evidence of active CNS disease may be eligible and enrolled if a compelling clinical rationale is provided by the Investigator and with documented Sponsor approval.
Other illness
- Has an active second cancer
- Has known Cytomegalovirus infection. Participants with negative status are eligible
- Has known hepatitis B or C infection or uncontrolled HIV
- Has known significant heart disease
Who the study is looking for
- Has been treated for the following blood cancers and has received at least 2 prior lines of systemic therapy or not eligible for available therapy:
- Diffuse large B-cell lymphoma - not otherwise specified
- High-grade B-cell lymphoma
- Diffuse large B-cell lymphoma - transformed from indolent lymphomas
- Follicular large B-cell lymphoma
- Follicular lymphoma
- Other non-Hodgkin lymphoma
- Has measurable disease
- Has discontinued all previous treatments for cancer and has recovered from the immediate effects of therapy
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (45)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universitaetsklinikum Koeln AöR Coordinator of this site? Confirm its status | Cologne | Germany | Not yet recruiting |
| Universitaetsklinikum Essen (AoR) Coordinator of this site? Confirm its status | Essen | Germany | Not yet recruiting |
| Goethe University Frankfurt Coordinator of this site? Confirm its status | Frankfurt Am Main | Germany | Not yet recruiting |
| Institut Catala D'oncologia Coordinator of this site? Confirm its status | L'Hospitalet de Llobregat | Spain | Not yet recruiting |
| Hospital Universitario Fundación Jiménez Díaz Coordinator of this site? Confirm its status | Madrid | Spain | Not yet recruiting |
| Centre Hospitalier Universitaire de Nantes Coordinator of this site? Confirm its status | Nantes | France | Withdrawn |
| Institut Curie Coordinator of this site? Confirm its status | Paris | France | Withdrawn |
| Centre Hospitalier Universitaire de Bordeaux Coordinator of this site? Confirm its status | Pessac | France | Withdrawn |
| Hospices Civils de Lyon Coordinator of this site? Confirm its status | Pierre-Bénite | France | Withdrawn |
| Oncopole Claudius Regaud Coordinator of this site? Confirm its status | Toulouse Cedex 9 | France | Withdrawn |
| The Royal Marsden NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Not yet recruiting |
| King's College Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Not yet recruiting |
| Nottingham City Hospital Coordinator of this site? Confirm its status | Nottingham | United Kingdom | Not yet recruiting |
| Derriford Hospital Coordinator of this site? Confirm its status | Plymouth | United Kingdom | Not yet recruiting |
| University Hospital Southampton NHS Foundation Trust Coordinator of this site? Confirm its status | Southampton | United Kingdom | Not yet recruiting |
| Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico Coordinator of this site? Confirm its status | Bologna | Italy | Not yet recruiting |
| Istituto Europeo di Oncologia s.r.l Coordinator of this site? Confirm its status | Milan | Italy | Not yet recruiting |
| National Cancer Center Hospital East Coordinator of this site? Confirm its status | Chiba | Japan | Not yet recruiting |
| Okayama University Hospital Coordinator of this site? Confirm its status | Okayama | Japan | Recruiting |
| Cancer Institute Hospital of JFCR Coordinator of this site? Confirm its status | Tokyo | Japan | Recruiting |
| Pratia S.A. Coordinator of this site? Confirm its status | Cracow | Poland | Not yet recruiting |
| Pratia Hematologia Sp. Z o. o Coordinator of this site? Confirm its status | Katowice | Poland | Not yet recruiting |
| Aidport sp z o.o. Coordinator of this site? Confirm its status | Skorzewo | Poland | Not yet recruiting |
| Instytut Hematologii I Transfuzjologii Coordinator of this site? Confirm its status | Warsaw | Poland | Not yet recruiting |
| Emory University Hospital Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Dana-Farber Cancer Institute Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| The Ohio State University (OSU) Coordinator of this site? Confirm its status | Columbus | United States | Recruiting |
| Texas Oncology - DFW (Sammons CC) Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| Colorado Blood Cancer Institute Coordinator of this site? Confirm its status | Denver | United States | Recruiting |
| City of Hope Coordinator of this site? Confirm its status | Duarte | United States | Recruiting |
| Baylor College of Medicine Coordinator of this site? Confirm its status | Houston | United States | Not yet recruiting |
| University of California, Los Angeles (UCLA) - Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| University of Miami - Sylvester Cancer Center Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| Froedtert Hospital and the Medical College of Wisconsin Coordinator of this site? Confirm its status | Milwaukee | United States | Recruiting |
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
| Sarah Cannon Research Institute Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
| Columbia University Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Oregon Health & Science University (OHSU) Coordinator of this site? Confirm its status | Portland | United States | Not yet recruiting |
| University of Rochester Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
| Mayo Clinic - Rochester Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
| University of California San Francisco (UCSF) - Helen Diller Family Comprehensive Cancer Center Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
| Florida Cancer Specialists - Sarasota Coordinator of this site? Confirm its status | Sarasota | United States | Recruiting |
| Mayo Clinic Scottsdale Coordinator of this site? Confirm its status | Scottsdale | United States | Recruiting |
| University of Washington - Fred Hutchinson Cancer Center (Seattle Cancer Care Alliance) Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.