NCT07227441Recruiting
Chronic Infections and Inflammation in ME/CFS: An Observational Study
Source: ClinicalTrials.gov · Last updated 6 Mar 2026
Brief summary (registry, in English)
CHIIME is a study of people who have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). People who do not have this condition will also be enrolled. Volunteers will be observed and sampled over time to identify the long-terms biological drivers and impact of their condition. The overall goal is to understand the biological and physiological mechanisms that are driving this condition.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 10 Nov 2025
- Start date
- 1 Jan 2026
- Primary completion date
- 30 Sept 2030
- Lead sponsor
- University of California, San Francisco
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT07227441
What you commit to
- Study type: Observational
- Planned participants: 200
- From 1 Jan 2026 to the primary completion date, 30 Sept 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Active drug or alcohol use or dependence that, in the opinion of the PI, would interfere with adherence to study requirements or to give informed consent
Other illness
- Known HIV, hepatitis B, or hepatitis C infection
- Diagnosis of an infection-associated chronic condition other than ME/CFS or Long COVID (e.g. chronic Lyme disease, post-Ebola syndrome, etc.)
- Serious medical or psychiatric illness that, in the opinion of the site investigator, would interfere with the ability to adhere to study requirements or to give informed consent
Lab values
- Self reported or documented chronic anemia with hemoglobin \<9 g/dL
Who the study is looking for
- Willing and able to provide written informed consent
- At least 18 years of age
- Either: (1) a reported diagnosis of ME/CFS or (2) no history of ME/CFS or other infection-associated chronic conditions (healthy control)
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Zuckerberg San Francisco General Hospital Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.