NCT07228052RecruitingPhase 4
Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department
Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department: A Randomized Control Trial
Source: ClinicalTrials.gov · Last updated 24 Jul 2026
Brief summary (registry, in English)
This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health System.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 182 (estimated)
- First submitted
- 12 Nov 2025
- Start date
- Jul 2026
- Primary completion date
- Dec 2026
- Lead sponsor
- Montefiore Medical Center
- Diseases
- Asthma
- NCT number
- NCT07228052
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 182
- From Jul 2026 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of systemic corticosteroids, including Emergency Medical Services (EMS) administration before ED arrival
Other illness
- History of severe adverse reactions to corticosteroids
Lab values
- Heart failure and uncontrolled diabetes (glucose \>300mg/dL in the ED)
Other
- Pregnancy or breastfeeding as prednisone is the preferred treatment for asthma in this population
- Inability to provide informed consent
Who the study is looking for
- Adults ≥18 years old presenting to the ED with an asthma exacerbation
- Diagnosed with asthma per International Classification of Diseases, 10th Revision (ICD-10) criteria or by the treating clinician
- Discharged from the ED with a primary diagnosis of asthma exacerbation
- Initiated systemic corticosteroids during the ED visit
- Must be English or Spanish speaking
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Montefiore Medical Center Coordinator of this site? Confirm its status | The Bronx | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.