NCT07228065Enrolling by invitation
Fixed-Dose Combinations Pragmatic Randomized Implementation Trial for Blood Pressure Control
Pharmacy-led Intervention to Increase the Adoption of Fixed-dose Single Pill Blood Pressure Lowering Medications: Hybrid Effectiveness-Implementation Trial
Source: ClinicalTrials.gov · Last updated 11 Aug 2026
Brief summary (registry, in English)
The proposed study is an effectiveness-implementation hybrid type II trial designed to evaluate the impact of provider- and patient-directed interventions on FDC use. The trial will test the effectiveness of theory-driven nudges tailored to address provider and patient barriers. All interventions will be pharmacist-driven, with pharmacists delivering information via nudges to providers and via nudges or more intensive interventions (i.e., CPA) to patients. Data to evaluate outcomes will be extracted from electronic health records.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 720 (estimated)
- First submitted
- 12 Nov 2025
- Start date
- 7 Aug 2026
- Primary completion date
- 30 Apr 2027
- Lead sponsor
- Brigham and Women's Hospital
- Diseases
- High blood pressure
- NCT number
- NCT07228065
What you commit to
- Study type: Interventional
- Planned participants: 720
- From 7 Aug 2026 to the primary completion date, 30 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- have received a prescription for a FDC in the preceding two years
Other illness
- have a documented allergy to any FDC components
- have a diagnosis of heart failure or renal failure, given that antihypertensive management in these populations typically requires disease-specific regimens and more frequent treatment adjustments
Other
- reside in a nursing home
- are pregnant
- preferred language is not English or Spanish, defined as documentation in the EHR indicating a primary language other than English or Spanish, or a documented request for an interpreter in a language other than Spanish
Who the study is looking for
- patients with documented hypertension diagnosis
- had an elevated ambulatory blood pressure reading during the qualifying visit (systolic \>140 mmHg or diastolic \>90 mmHg
- have an upcoming scheduled visit
- have an active prescription for 1 blood pressure lowering medication with a fixed-dose combination (FDC) alternative
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Advocate Health Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.