NCT07228221RecruitingPhase 4
Standalone iStent Infinite and iDose TR for Management of Moderate to Severe Open Angle Glaucoma
iStent Infinite and iDose TR for Management of Moderate to Severe Primary Open Angle Glaucoma Are a Safe and Effective Alternative to Filtering Surgery for IOP Reduction in Patients With Medically Uncontrolled Glaucoma. (POAG)
Source: ClinicalTrials.gov · Last updated 14 Nov 2025
Brief summary (registry, in English)
The Investigators will investigate the efficacy of combining the standalone iStent infinite and iDose that are minimally invasive surgical and drug depot options are a safe and effective alternative to filtering surgery for intraocuar pressure reduction in patients with medically uncontrolled open angle glaucoma.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 13 Nov 2025
- Start date
- Jan 2026
- Primary completion date
- Aug 2031
- Lead sponsor
- Jonathon Myers
- Diseases
- Glaucoma
- NCT number
- NCT07228221
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 20
- From Jan 2026 to the primary completion date, Aug 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous incisional glaucoma surgery
Lab values
- ALT; History of iridotomy, SLT, or micropulse laser trabeculoplasty within the prior 90 days
Other
- Traumatic, uveitic, neovascular glaucoma, or angle closure glaucoma
- Active ocular inflammation or edema, clinically significant corneal dystrophy
- Corneal or other pathology preventing accurate Goldmann applanation tonometry
Who the study is looking for
- Moderate to severe open angle glaucoma (including POAG, PG, and PXG)
- Open angle configuration (Shaffer grade ≥ 3), normal angle anatomy9
- Visual acuity HM or better
- VF MD -6dB or worse
- Failed medical therapy and/or laser treatment
- Incisional glaucoma surgery contemplated as next intervention
- Phakic or pseudophakic
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Wills Eye Hosital Glaucoma Dept. Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.