NCT07229196Recruiting
Clinical Trial in Hypertensive Patients Comparing Two Cardiorespiratory Exercise Protocols, Low-volume Sprint Interval Training (SIT) Versus Moderate-intensity Continuous Training (MICT), to Evaluate Decreases in Ambulatory Blood Pressure and Other Clinical Variables.
Source: ClinicalTrials.gov · Last updated 14 Nov 2025
Brief summary (registry, in English)
This randomized clinical trial aims to compare two cardiorespiratory exercise training protocols - Sprint Interval Training (SIT), characterized by short, maximal-intensity efforts, versus Moderate-Intensity Continuous Training (MICT) - in patients with arterial hypertension. The primary objective is to evaluate the impact of both interventions on 24-hour ambulatory systolic blood pressure (ABPM) after a 12-week training period. Secondary outcomes include diastolic, daytime, and nighttime blood pressure, metabolic and hemodynamic parameters, body composition, and serum myokine levels (IL-6 and α-CGRP). Participants aged 30-59 years with diagnosed hypertension but without high cardiovascular risk will be recruited from the Cardio-Metabolic Disease Unit of Hospital San Martín (La Plata, Argentina). After a two-week familiarization period, eligible participants will be randomized to SIT or MICT groups. The intervention will last 12 weeks, with three supervised sessions per week. The study will provide valuable information about the effectiveness, safety, and clinical applicability of brief, high-intensity exercise for blood pressure control in hypertensive patients.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 13 Nov 2025
- Start date
- 29 Apr 2025
- Primary completion date
- 30 Nov 2026
- Lead sponsor
- Unidad Enfermedades Cardiometabolicas- Hospital Interzonal General Agudos San Martin de La Plata
- Diseases
- High blood pressure
- NCT number
- NCT07229196
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 29 Apr 2025 to the primary completion date, 30 Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with high cardiovascular risk conditions such as type II diabetes, chronic kidney disease (\<60 milliseconds), history of cerebrovascular disease, coronary artery disease, peripheral arterial disease, or heart failure (Framingham Criteria clinical diagnosis).
- Patients with a history of active malignant neoplastic disease under treatment.
- Elimination Criteria
- -Patients whose pharmacological treatment is initiated or modified during the follow-up after 3 months.
Other
- Extreme body mass index (BMI) \<18.5 and ≥35.
- Patients with office blood pressure readings ≥160/100 mmHg.
- Pregnant or postpartum women up to 3 months old.
- Patients with psychophysical limitations that make exercise difficult.
Who the study is looking for
- Patients of both sexes between 30-59 years of age who meet the definition of hypertension.
- Hypertension will be defined as:
- Those patients who report a history of hypertension and are under pharmacological treatment for it (Angiotensin Converting Enzyme Inhibitors/Angiotensin II Receptor Antagonists/Calcium Channel Blockers/Thiazide Diuretics/Beta Blockers) at the time of the evaluation.
- OR
- Patients who report a history of hypertension during the evaluation and who, without pharmacological treatment, have average levels ≥140/90 mmHg will also be considered hypertensive.
Age in the registry: 30 years to 59 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Interzonal General San Martin La Plata Coordinator of this site? Confirm its status | La Plata | Argentina | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.