NCT07229482Recruiting
Potatoes, Type 2 Diabetes, and Cardiometabolic Health
Cardiometabolic Effects of a Potato-rich Diet in Older Adults at Increased Risk of Developing Type 2 Diabetes: A Randomized Controlled Feeding Study
Source: ClinicalTrials.gov · Last updated 3 Sept 2026
Brief summary (registry, in English)
Type 2 diabetes (T2D) is a major chronic health condition which increases risk of coronary artery disease, frailty, cognitive decline, and mortality. Additionally, hypertension is a major comorbidity for individuals with T2D, further increasing the risk of adverse cardiovascular outcomes. The prevalence of both conditions increases with advancing age. There is an urgent need to identify new approaches to prevent the development of T2D and improve cardiometabolic health in older adults 50-70 years of age. Whole white potatoes are an unprocessed food rich in essential nutrients often under-consumed by Americans, including potassium, fiber, magnesium, vitamins C and B6, and phytochemicals. Each of these nutrients individually are associated with cardiometabolic health benefits. Potatoes account for a significant amount of the intake of these nutrients in the US diet and are well-positioned to be a foundational element of a healthy dietary pattern. However, there are few interventional studies evaluating the effect of potatoes on cardiometabolic health, and the evidence from observational studies is mixed, leaving a significant gap in knowledge regarding the potential for potatoes to be included in healthy dietary patterns. The results of our proposed study will provide foundational data that inform future dietary guidelines regarding the inclusion of white potatoes as part of a healthy US dietary pattern.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 42 (estimated)
- First submitted
- 12 Nov 2025
- Start date
- 27 Aug 2026
- Primary completion date
- 31 Oct 2028
- Lead sponsor
- Virginia Polytechnic Institute and State University
- Diseases
- Type 2 diabetes
- NCT number
- NCT07229482
What you commit to
- Study type: Interventional
- Planned participants: 42
- From 27 Aug 2026 to the primary completion date, 31 Oct 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Antibiotic, prebiotic or probiotic use in prior 3 months
- Estrogen or testosterone usage, lipid-lowering medication, blood pressure medication usage \<6 months
Other illness
- Diabetes or diabetes medication
- Diagnosed inflammatory bowel disease
- Past or current heart diseases, stroke, respiratory disease, endocrine or metabolic disease, or hematological-oncological disease
- Food allergies or aversions to diet foods provided
Lab values
- Weight loss medication or medication influencing glucose metabolism
- TCHOL \>6.2 mmol/L; TG \>4.5 mmol/L
Other
- Body mass index \>40 m2/kg
- Blood pressure (BP) \> 159/99 mmHg
- Vegetarian or vegan
- Pregnant or plans to become pregnant
Who the study is looking for
- Age 50-70 years
- Weight stable for previous 3 months (±5% body weight)
- Sedentary to recreationally active
- ADA-Risk Screener questionnaire score of at least 5
- No plans to gain or lose weight or change physical activity level
- Willing to pick up food daily and consume foods provided for a 14-week period
- Verbal and written informed consent
- Estrogen or testosterone use, lipid-lowering or blood pressure medication and thyroid replacement medication is acceptable, if on stable dose for \>6 months
Age in the registry: 50 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Virginia Polytechnic Institute and State University Coordinator of this site? Confirm its status | Blacksburg | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.