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NCT07229729RecruitingPhase 2

A Study of SHR-A2102 in Combination With Other Anti-tumor Therapies for Resectable Non-small Cell Lung Cancer

A Randomized, Open-label, Multicenter Phase II Clinical Study of SHR-A2102 in Combination With Other Anti-tumor Therapies for Perioperative Treatment of Resectable Non-small Cell Lung Cancer

Source: ClinicalTrials.gov · Last updated 1 Dec 2025

Brief summary (registry, in English)

The study is a Phase II study to explore the efficacy and safety of SHR-A2102 in combination with other anti-tumor therapies as perioperative treatment in patients with resectable non-small cell lung cancer.

Status (registry)
Recruiting
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
300 (estimated)
First submitted
13 Nov 2025
Start date
24 Nov 2025
Primary completion date
31 Oct 2026
Lead sponsor
Shanghai Hengrui Pharmaceutical Co., Ltd.
Diseases
Lung cancer
NCT number
NCT07229729

What you commit to

  • Study type: Interventional · Phase 2
  • Planned participants: 300
  • From 24 Nov 2025 to the primary completion date, 31 Oct 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Malignancies other than NSCLC within 5 years prior to randomization;

Other illness

  • With active, known or suspected autoimmune disease of autoimmune disease;
  • Has or suspected has a history of pneumonitis / interstitial lung disease or any serve lung diseases which will influence the examination of lung function;
  • Significant history of cardiovascular and cerebrovascular disease; Significant haemorrhagic disease;
  • Has a known history of human immunodeficiency virus (HIV) infection;
  • Has a known active Hepatitis B or Hepatitis C;
  • Allergic to the intervention regimens.

Other

  • Has an arteriovenous thrombotic events;

Who the study is looking for

  • Voluntarily participate in this clinical study, understand the research procedures and be able to sign the informed consent form in writing;
  • Participants must be aged between 18 and 70 years old (inclusive) when signing the informed consent form, and both men and women are eligible;
  • Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1;
  • Adequate organ function;
  • Women of childbearing age must undergo serum pregnancy tests, and the results must be negative. Female subjects of childbearing age and male subjects who are partners of women of childbearing age must agree to use highly effective contraceptive methods.

Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Guangdong Provincial People's Hospital
Coordinator of this site? Confirm its status
GuangzhouChinaRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.