NCT07230145Not yet recruitingPhase 1
A Trial of SHR-4658 in Healthy Volunteers or Volunteers With Elevated Blood Pressure
A Double-Blind, Randomized, Dose-Escalating Phase I Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Dose SHR-4658 in Healthy Volunteers or Volunteers With Elevated Blood Pressure
Source: ClinicalTrials.gov · Last updated 17 Nov 2025
Brief summary (registry, in English)
This is a clinical study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamic and immunogenicity of single subcutaneous injection of SHR-4658 in healthy volunteers and volunteers with elevated blood pressure.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 48 (estimated)
- First submitted
- 13 Nov 2025
- Start date
- Nov 2025
- Primary completion date
- Jun 2026
- Lead sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
- Diseases
- Heart failure, High blood pressure
- NCT number
- NCT07230145
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 48
- From Nov 2025 to the primary completion date, Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participated in clinical trials of other drugs or medical devices.
Other illness
- Known history or current clinically significant disease.
- Protocol-defined risk factors for disease.
Other
- Pregnant or nursing women.
Who the study is looking for
- Able and willing to provide a written informed consent.
- Blood pressure as defined in the protocol.
- Male or female，aged 18 to 55 years (inclusive).
- Meet the weight standard.
Age in the registry: 18 years to 55 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Anzhen Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.