NCT07230834RecruitingPhase 1
Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult Participants
A Phase 1 Dose-Escalation and Repeated-Dose Study of the Safety and Tolerability of Intravitreal Pozelimab in Participants With Geographic Atrophy
Source: ClinicalTrials.gov · Last updated 5 Aug 2026
Brief summary (registry, in English)
This study is researching an experimental drug called pozelimab (called "study drug"). The study is focused on people with a condition where certain parts of the eye's retina stop working over time, which can make it harder to see. This is called geographic atrophy (GA). The aim of the study is to see how safe and tolerable the study drug is when used as an injection in the eye. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood and the fluid in the eye at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 54 (estimated)
- First submitted
- 13 Nov 2025
- Start date
- 19 Jan 2026
- Primary completion date
- 3 Jul 2028
- Lead sponsor
- Regeneron Pharmaceuticals
- Diseases
- Macular degeneration
- NCT number
- NCT07230834
- EU CT number
- 2025-521758-40-00
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 54
- From 19 Jan 2026 to the primary completion date, 3 Jul 2028
- 9 sites in 4 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent eye disease (elevated Intraocular Pressure (IOP) \>25mm Hg, diabetic retinopathy, ocular infections/inflammation)
- Prior or current intravitreal (IVT) treatment of any kind for any indication in either the study or fellow eye, except complement inhibitor therapy for GA, as long as last dose was ≥3 months prior to screening
- Any prior systemic treatment for dry AMD, except oral supplements or vitamins
- History or current use of systemic complement inhibitor therapy
- Note: Other protocol-defined Inclusion/ Exclusion criteria apply
Other
- GA (macular atrophy) in either eye due to causes other than dry AMD
- History or current evidence of macular neovascularization and/or retinal exudation in either eye
Who the study is looking for
- Study eye with diagnosis of GA of the macula secondary to AMD, as determined by the investigator
- Study eye with total GA area measuring approximately one disc area or greater in size (2.5 mm\^2 or larger) at screening, as determined by the Central Reading Center (CRC), as described in the protocol
- Best-Corrected Visual Acuity (BCVA) of 60 letters or worse using the Early Treatment Diabetic Retinopathy Score (ETDRS) charts (Snellen equivalent of \~ ≤20/63) in the study eye at screening and baseline visit
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (9)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Arensia Exploratory Medicine at the Research Institute of Clinical Medicine Coordinator of this site? Confirm its status | Tbilisi | Georgia | Recruiting |
| Emanuelli Research and Development Center Coordinator of this site? Confirm its status | Arecibo | Puerto Rico | Recruiting |
| Arensia Clinics S.R.L. Coordinator of this site? Confirm its status | Bucharest | Romania | Recruiting |
| Spitalul Clinic Judetean De Urgenta Cluj Coordinator of this site? Confirm its status | Cluj-Napoca | Romania | Recruiting |
| Austin Retina Associates Coordinator of this site? Confirm its status | Austin | United States | Recruiting |
| Retina Foundation of the Southwest Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| Ophthalmic Consultants of Boston Coordinator of this site? Confirm its status | East Weymouth | United States | Recruiting |
| Colorado Retina Associates Coordinator of this site? Confirm its status | Lakewood | United States | Recruiting |
| Retina Consultants Texas Coordinator of this site? Confirm its status | The Woodlands | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.