NCT07232498Recruiting
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke - a Randomized Clinical Trial
Source: ClinicalTrials.gov · Last updated 29 Sept 2026
Brief summary (registry, in English)
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability. In this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1300 (estimated)
- First submitted
- 16 Sept 2025
- Start date
- 4 Jun 2025
- Primary completion date
- Dec 2026
- Lead sponsor
- Unidade Local de Saúde de Coimbra, EPE
- Diseases
- Stroke
- NCT number
- NCT07232498
What you commit to
- Study type: Interventional
- Planned participants: 1300
- From 4 Jun 2025 to the primary completion date, Dec 2026
- 7 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concomitant diagnosis of a rapidly progressive fatal disease (e.g., terminal-stage cancer);
- Requirement for continuous monitoring or continuous intravenous drug infusion;
Other illness
- Heart rate \< 40 or \> 112 beats per minute;
- Acute deep vein thrombosis/pulmonary embolism.
Other
- Pre-existing disability with a modified Rankin Scale (mRS) score ≥ 4;
- Diagnosis of Transient Ischemic Attack (TIA);
- Severe hemodynamic instability, defined as:
- Systolic blood pressure \< 100 mmHg or \> 220 mmHg;
- Peripheral oxygen saturation \< 92%;
- Body temperature \> 38.5°C;
- Neurological deterioration with altered level of consciousness (defined as Glasgow Coma Scale \< 10);
- Patients who underwent neurosurgical intervention within the past 30 days;
Who the study is looking for
- Patients diagnosed with ischemic stroke aged 18 years or older;
- Ability to undergo carotid and transcranial Doppler ultrasound, as well as to mobilize within 48 hours;
- Informed consent obtained from the patient or legal representative.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (7)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Rijeka Coordinator of this site? Confirm its status | Rijeka | Croatia | Not yet recruiting |
| University Hospital Center Zagreb Coordinator of this site? Confirm its status | Zagreb | Croatia | Not yet recruiting |
| Unidade Local de Saude de Coimbra Coordinator of this site? Confirm its status | Coimbra | Portugal | Recruiting |
| ULS São José Coordinator of this site? Confirm its status | Lisbon | Portugal | Recruiting |
| Unidade Local de Saúde de Santa Maria Coordinator of this site? Confirm its status | Lisbon | Portugal | Not yet recruiting |
| Unidade Local de Saúde de São João Coordinator of this site? Confirm its status | Porto | Portugal | Not yet recruiting |
| Unidade Local de Saude de Matosinhos Coordinator of this site? Confirm its status | Porto | Portugal | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.