NCT07232719Active, not recruitingPhase 3
A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
A Phase 3b Study to Investigate the Efficacy and Safety of Retatrutide Once Weekly in Participants Without Type 2 Diabetes Who Have Obesity or Overweight: A Randomized, Double-Blind, Placebo-Controlled Trial
Source: ClinicalTrials.gov · Last updated 17 Apr 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the efficacy and safety of retatrutide compared with placebo for body weight reduction. Participation in the study will last about 65 weeks and may include about 18 visits.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 250 (estimated)
- First submitted
- 14 Nov 2025
- Start date
- 17 Nov 2025
- Primary completion date
- Jul 2027
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT07232719
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 250
- From 17 Nov 2025 to the primary completion date, Jul 2027
- 31 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have a self-reported change in body weight \>5 kg (11 pounds) within 90 days before screening
- Have a prior or planned surgical treatment for obesity
- Have had within the past 90 days before screening
- acute myocardial infarction
- cerebrovascular accident (stroke)
- hospitalization for unstable angina, or
- hospitalization due to congestive heart failure
- Have taken weight loss drugs, including over-the counter medications within 90 days prior to screening
Other illness
- Have type 1 diabetes or type 2 diabetes
- Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
- Have New York Heart Association Functional Classification Class IV congestive heart failure
- Have a history of chronic or acute pancreatitis
Who the study is looking for
- Have a body mass index (BMI) of:
- ≥30 kilogram per square meter (kg/m2) OR
- ≥27 kg/m2 with at least one of the following weight-related conditions: high blood pressure, abnormal levels of lipid, obstructive sleep apnea, heart disease
- Have at least one unsuccessful attempt to lose weight by dieting
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (31)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| FutureMeds - Birmingham Coordinator of this site? Confirm its status | Birmingham | United Kingdom | Unknown status |
| Layton Medical Centre Coordinator of this site? Confirm its status | Blackpool | United Kingdom | Unknown status |
| Bradford on Avon Health Centre Coordinator of this site? Confirm its status | Bradford on Avon | United Kingdom | Unknown status |
| FutureMeds - Liverpool Coordinator of this site? Confirm its status | Bromborough | United Kingdom | Unknown status |
| Cheadle Community Hospital Coordinator of this site? Confirm its status | Cheadle | United Kingdom | Unknown status |
| HMC Health Group - Meadows Centre for Health Coordinator of this site? Confirm its status | Hounslow | United Kingdom | Unknown status |
| St Bartholomew's Medical Centre Coordinator of this site? Confirm its status | Oxford | United Kingdom | Unknown status |
| Atlantic Medical Coordinator of this site? Confirm its status | Penzance | United Kingdom | Unknown status |
| The Adam Practice Coordinator of this site? Confirm its status | Poole | United Kingdom | Unknown status |
| Woodstock Bower Surgery Coordinator of this site? Confirm its status | Rotherham | United Kingdom | Unknown status |
| Rame Group Practice Coordinator of this site? Confirm its status | Torpoint | United Kingdom | Unknown status |
| Albany House Medical Centre Coordinator of this site? Confirm its status | Wellingborough | United Kingdom | Unknown status |
| Care Access - Arlington Heights Coordinator of this site? Confirm its status | Arlington Heights | United States | Unknown status |
| JEM Research Institute Coordinator of this site? Confirm its status | Atlantis | United States | Unknown status |
| Pharmasite Research, Inc. Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Clinical Research Professionals Coordinator of this site? Confirm its status | Chesterfield | United States | Unknown status |
| Cedar Health Research Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Headlands Research-El Paso Coordinator of this site? Confirm its status | El Paso | United States | Unknown status |
| Cedar Health Research - Euless Coordinator of this site? Confirm its status | Euless | United States | Unknown status |
| Cedar Health Research - Fort Worth Coordinator of this site? Confirm its status | Fort Worth | United States | Unknown status |
| Care Access - Houston Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| L-MARC Research Center Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| IMA Clinical Research Monroe - Armand Coordinator of this site? Confirm its status | Monroe | United States | Unknown status |
| Ima Clinical Research Manhattan Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Headlands Research Orlando Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Artemis Institute for Clinical Research Coordinator of this site? Confirm its status | Riverside | United States | Unknown status |
| IMA Clinical Research San Antonio Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Clinvest Headlands LLC Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Care Access - Tamarac Coordinator of this site? Confirm its status | Tamarac | United States | Unknown status |
| IMA Clinical Research Warren Coordinator of this site? Confirm its status | Warren Township | United States | Unknown status |
| Trial Management Associates - Wilmington - Floral Parkway Coordinator of this site? Confirm its status | Wilmington | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.