NCT07233902Completed
MS Synchronous vs Asynchronous Exercise Study
Comparison of the Effects of Synchronous and Asynchronous Exercise Programs in Patients With Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 21 Jan 2026
Brief summary (registry, in English)
This randomized controlled study aims to compare the effects of synchronous and asynchronous exercise programs on individuals diagnosed with relapsing-remitting multiple sclerosis (RRMS). Participants meeting the inclusion criteria (EDSS score between 2 and 5.5, aged 18-55) were randomly assigned to either the Synchronous Exercise Group (SEG) or the Asynchronous Exercise Group (ASEG). The synchronous program was delivered via live online sessions using Google Meet and WhatsApp video calls, while the asynchronous program consisted of pre-recorded exercise videos accessible to participants. Both programs included structured exercises focusing on functional capacity, muscle strength, fatigue, independence, and quality of life. The sample size was determined using G\*Power software based on previous studies in individuals with multiple sclerosis, targeting a total of 16. Statistical analyses will be conducted using SPSS 26.0. Parametric and non-parametric tests will be used depending on data distribution, with significance set at p \< 0.05. The study seeks to improve accessibility to exercise programs for MS patients and provide evidence for the efficacy of remotely delivered synchronous versus asynchronous rehabilitation models.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 16 (actual)
- First submitted
- 13 Nov 2025
- Start date
- 1 Apr 2025
- Primary completion date
- 1 Oct 2025
- Lead sponsor
- Yeditepe University
- Diseases
- Multiple sclerosis
- NCT number
- NCT07233902
What you commit to
- Study type: Interventional
- Participants enrolled: 16
- From 1 Apr 2025 to the primary completion date, 1 Oct 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any vestibular, cardiovascular, or orthopedic condition that limits exercise participation or increases fall risk (Jallouli et al., 2022).
- Presence of a psychiatric diagnosis.
Other
- Presence of any neurological diagnosis other than MS.
- Mini-Mental State Examination (MMSE) score below 24.
- Timed Up and Go (TUG) test result greater than 14.2 seconds, indicating elevated fall risk (Block et al., 2022).
- Severe visual or auditory impairments.
- Current participation in another exercise or physiotherapy/rehabilitation program.
- Pregnancy.
Who the study is looking for
- Diagnosis of Relapsing-Remitting Multiple Sclerosis (RRMS) according to the McDonald criteria.
- Age between 18 and 55 years.
- Expanded Disability Status Scale (EDSS) score between 2.0 and 5.5.
- No relapse within the last six months.
- Access to the necessary technological infrastructure (internet, camera, and microphone) to participate in the synchronous exercise program.
Age in the registry: 18 years to 55 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Yeditepe University Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.