Sign in

NCT07235293RecruitingPhase 2

A Study to Test DSP107 in Combination With Atezolizumab in Comparison With Fruquintinib as a New Treatment for Colorectal Cancer.

A Randomized, Open-label, Phase 2b Study to Compare the Efficacy of DSP107 in Combination With Atezolizumab Versus Fruquintinib in Patients With Advanced Microsatellite Stable Colorectal Cancer

Source: ClinicalTrials.gov · Last updated 20 Aug 2026

Brief summary (registry, in English)

This clinical study is testing whether a new combination of medicines (DSP107 and atezolizumab) is more effective and safer than an existing treatment (fruquintinib) for people with advanced colorectal cancer that is microsatellite stable (MSS). Participants will be randomly assigned to receive one of the two treatments, and researchers will monitor how well the cancer responds, how safe the treatments are, and how the body processes them. The study hopes to show that the new combination can improve outcomes for patients with this type of colorectal cancer.

Status (registry)
Recruiting
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
90 (estimated)
First submitted
3 Nov 2025
Start date
16 Jan 2026
Primary completion date
30 Sept 2026
Lead sponsor
Kahr Bio Australia Pty Ltd
NCT number
NCT07235293

What you commit to

  • Study type: Interventional · Phase 2
  • Planned participants: 90
  • From 16 Jan 2026 to the primary completion date, 30 Sept 2026
  • 18 sites in 2 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Central nervous system (CNS) metastases unless stable 2 months post definitive therapy with steroids.
  • Unresolved AEs of Grade 2 or higher from prior anticancer therapy.
  • Current or recent treatment with certain therapies including specified anticancer treatments, modulators of CYP3A4 and immunomodulating therapies (prior treatment with CPIs is not exclusory).

Other illness

  • Past or current history of autoimmune disease or immune deficiency.
  • History of other malignancy within 3 years of first study treatment cycle.
  • Known allergy or hypersensitivity to any of the test compounds, materials, or contraindication to test product.

Lab values

  • Clinically significant abnormal laboratory safety tests.

Who the study is looking for

  • Are ≥ 18 years of age with a life expectancy of \> 3 months.
  • Participants with histologically confirmed, inoperable, MSS and/or pMMR CRC which has progressed to, or is intolerant to, specified therapies (and has received prior treatment with no more than 3 lines of therapy).
  • Measurable disease per RECIST v1.1.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (18)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Flinders Medical Centre SA
Coordinator of this site? Confirm its status
Bedford ParkAustraliaRecruiting
Chris O'Brien Lifehouse
Coordinator of this site? Confirm its status
CamperdownAustraliaRecruiting
Monash Health
Coordinator of this site? Confirm its status
ClaytonAustraliaRecruiting
Footscray Hospital - Western Health
Coordinator of this site? Confirm its status
FootscrayAustraliaRecruiting
Austin Health
Coordinator of this site? Confirm its status
HeidelbergAustraliaRecruiting
Alfred Hospital
Coordinator of this site? Confirm its status
MelbourneAustraliaRecruiting
Sir Charles Gairdner Hospital
Coordinator of this site? Confirm its status
NedlandsAustraliaRecruiting
Port Macquarie Base Hospital (Mid North Coast Cancer Institute), Wrights Road,
Coordinator of this site? Confirm its status
Port MacquarieAustraliaRecruiting
Sunshine Hospital - Western Health
Coordinator of this site? Confirm its status
Saint AlbansAustraliaRecruiting
Icon Cancer Centre
Coordinator of this site? Confirm its status
South BrisbaneAustraliaRecruiting
Westmead Hospital
Coordinator of this site? Confirm its status
WestmeadAustraliaRecruiting
The Queen Elizabeth Hospital
Coordinator of this site? Confirm its status
WoodvilleAustraliaRecruiting
University of Colorado Hospital- Anschutz Cancer Center Pavillion (ACP)
Coordinator of this site? Confirm its status
AuroraUnited StatesRecruiting
Duke University Medical Center - Duke Cancer Center
Coordinator of this site? Confirm its status
DurhamUnited StatesRecruiting
Mayo Clinic
Coordinator of this site? Confirm its status
Florida CityUnited StatesRecruiting
University of Colorado Cancer Center - Highlands Ranch Hospital
Coordinator of this site? Confirm its status
Highlands RanchUnited StatesRecruiting
UPMC Hillman Cancer Center
Coordinator of this site? Confirm its status
PittsburghUnited StatesRecruiting
The University of Texas MD Anderson Cancer Center
Coordinator of this site? Confirm its status
Texas CityUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.