NCT07235293RecruitingPhase 2
A Study to Test DSP107 in Combination With Atezolizumab in Comparison With Fruquintinib as a New Treatment for Colorectal Cancer.
A Randomized, Open-label, Phase 2b Study to Compare the Efficacy of DSP107 in Combination With Atezolizumab Versus Fruquintinib in Patients With Advanced Microsatellite Stable Colorectal Cancer
Source: ClinicalTrials.gov · Last updated 20 Aug 2026
Brief summary (registry, in English)
This clinical study is testing whether a new combination of medicines (DSP107 and atezolizumab) is more effective and safer than an existing treatment (fruquintinib) for people with advanced colorectal cancer that is microsatellite stable (MSS). Participants will be randomly assigned to receive one of the two treatments, and researchers will monitor how well the cancer responds, how safe the treatments are, and how the body processes them. The study hopes to show that the new combination can improve outcomes for patients with this type of colorectal cancer.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 90 (estimated)
- First submitted
- 3 Nov 2025
- Start date
- 16 Jan 2026
- Primary completion date
- 30 Sept 2026
- Lead sponsor
- Kahr Bio Australia Pty Ltd
- Diseases
- Colorectal cancer
- NCT number
- NCT07235293
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 90
- From 16 Jan 2026 to the primary completion date, 30 Sept 2026
- 18 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Central nervous system (CNS) metastases unless stable 2 months post definitive therapy with steroids.
- Unresolved AEs of Grade 2 or higher from prior anticancer therapy.
- Current or recent treatment with certain therapies including specified anticancer treatments, modulators of CYP3A4 and immunomodulating therapies (prior treatment with CPIs is not exclusory).
Other illness
- Past or current history of autoimmune disease or immune deficiency.
- History of other malignancy within 3 years of first study treatment cycle.
- Known allergy or hypersensitivity to any of the test compounds, materials, or contraindication to test product.
Lab values
- Clinically significant abnormal laboratory safety tests.
Who the study is looking for
- Are ≥ 18 years of age with a life expectancy of \> 3 months.
- Participants with histologically confirmed, inoperable, MSS and/or pMMR CRC which has progressed to, or is intolerant to, specified therapies (and has received prior treatment with no more than 3 lines of therapy).
- Measurable disease per RECIST v1.1.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (18)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Flinders Medical Centre SA Coordinator of this site? Confirm its status | Bedford Park | Australia | Recruiting |
| Chris O'Brien Lifehouse Coordinator of this site? Confirm its status | Camperdown | Australia | Recruiting |
| Monash Health Coordinator of this site? Confirm its status | Clayton | Australia | Recruiting |
| Footscray Hospital - Western Health Coordinator of this site? Confirm its status | Footscray | Australia | Recruiting |
| Austin Health Coordinator of this site? Confirm its status | Heidelberg | Australia | Recruiting |
| Alfred Hospital Coordinator of this site? Confirm its status | Melbourne | Australia | Recruiting |
| Sir Charles Gairdner Hospital Coordinator of this site? Confirm its status | Nedlands | Australia | Recruiting |
| Port Macquarie Base Hospital (Mid North Coast Cancer Institute), Wrights Road, Coordinator of this site? Confirm its status | Port Macquarie | Australia | Recruiting |
| Sunshine Hospital - Western Health Coordinator of this site? Confirm its status | Saint Albans | Australia | Recruiting |
| Icon Cancer Centre Coordinator of this site? Confirm its status | South Brisbane | Australia | Recruiting |
| Westmead Hospital Coordinator of this site? Confirm its status | Westmead | Australia | Recruiting |
| The Queen Elizabeth Hospital Coordinator of this site? Confirm its status | Woodville | Australia | Recruiting |
| University of Colorado Hospital- Anschutz Cancer Center Pavillion (ACP) Coordinator of this site? Confirm its status | Aurora | United States | Recruiting |
| Duke University Medical Center - Duke Cancer Center Coordinator of this site? Confirm its status | Durham | United States | Recruiting |
| Mayo Clinic Coordinator of this site? Confirm its status | Florida City | United States | Recruiting |
| University of Colorado Cancer Center - Highlands Ranch Hospital Coordinator of this site? Confirm its status | Highlands Ranch | United States | Recruiting |
| UPMC Hillman Cancer Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Recruiting |
| The University of Texas MD Anderson Cancer Center Coordinator of this site? Confirm its status | Texas City | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.