NCT07237048RecruitingPhase 2/3
Minocycline in Stroke Study at Maimonides
Effect of Oral Minocycline in Patients With Acute Stroke - a Randomized, Open Label, Prospective Trial
Source: ClinicalTrials.gov · Last updated 19 Mar 2026
Brief summary (registry, in English)
The goal of this study is to determine if Minocycline, when added to standard care, can improve survival and functional outcomes in patients with moderate acute stroke (ischemic or hemorrhagic) aged 18 years and older. The main questions it aims to answer are: 1. Does Minocycline improve \*National Institutes of Health Stroke Scale\* (NIHSS) scores at hospital discharge and 90 days post-stroke? 2. Does Minocycline reduce stroke-related disability, all-cause in hospital mortality (mRS -\*Modified Rankin Scale\* = 6) and at 90 days besides reducing brain bleeding complications compared to standard care? Researchers will compare patients receiving oral Minocycline plus standard care to those receiving standard care only to see if Minocycline leads to better neurological outcomes and lower mortality. Participants will: 1. Be randomly assigned by block to receive either: Minocycline 200 mg orally once daily for five days within 24 hours from symptoms onset + Standard Care, or Standard Care only 2. Undergo neurological assessments using NIHSS \*National Institutes of Health Stroke Scale\* and Modified Rankin Scale (mRS) at admission, discharge, 30 days post-stroke, 90 days post-stroke 3. Be monitored for: a) hemorrhagic transformation of ischemic strokes; b) Adverse events and mortality outcomes; c) Safety and efficacy signals through interim analyses NIHSS: \*National Institutes of Health Stroke Scale\*, which is stroke severity scale, mRS: \*Modified Rankin Scale\*, which is stroke disability scale
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 1164 (estimated)
- First submitted
- 23 Oct 2025
- Start date
- 2 Feb 2026
- Primary completion date
- 1 Dec 2028
- Lead sponsor
- Joyce Chen
- Diseases
- Stroke
- NCT number
- NCT07237048
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 1164
- From 2 Feb 2026 to the primary completion date, 1 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- \* Inclusion criteria
- In order to be eligible to participate in this study, an individual must meet all of the following criteria:
- Age \>/=18
- NIHSS 5-20 \*National Institutes of Health Stroke Scale\*
- Acute onset neurological deficit consistent with acute ischemic stroke or on imaging consistent with acute ischemia as defined by WHO \*(World Health Organization) \* guidelines or acute onset of neurological deficits with intracerebral Hemorrhage on imaging consistent with intracerebral bleed
- The onset of neurological symptoms less than 24 hours
- Exclusion criteria
- An individual who meets any of the following criteria is excluded from participation in this study:
- Clinically stroke is not suspected
- Allergic to the Tetracycline group of medications or Intolerance to Minocycline
- Pregnancy or suspected pregnancy or breastfeeding
- Previous history of intolerance to Minocycline
- Acute or chronic renal failure (stage III with GFR \*(Glomerular Filtration Rate) \* or Creatinine threshold)
- Any patients with contraindications to undergo CT (Computed Tomography) / MRI (Magnetic Resonance Imaging)
- Life expectancy less than one year or severe co-morbidities or comfort measure only (CMO) on admission
- Pre-existing infectious disease requiring antibiotics
- Inability to tolerate enteral medications/feeds
- Patient/ family refusal
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Maimonides Medical Center Coordinator of this site? Confirm its status | Brooklyn | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.