NCT07237204Not yet recruiting
15 vs 45 Minute Pringle Maneuver in Liver Cancer Resection: Randomized Noninferiority Trial
A Prospective, Randomized Noninferiority Trial Comparing 15- and 45-minute Pringle Maneuvers During Liver Resection for Oncologic Indications.
Source: ClinicalTrials.gov · Last updated 19 Nov 2025
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate the safety of two durations of the Pringle maneuver in adults undergoing elective liver resection for malignant tumors. The main questions it aims to answer are: Is the incidence of post-hepatectomy liver failure different between 15-minute and 45-minute Pringle maneuver durations? * Do the durations differ in operative time or intraoperative blood loss? * Researchers will compare patients randomized 1:1 to 15 minutes vs 45 minutes of Pringle clamping to see if outcomes are non-inferior between groups. Participants will: * Undergo standard oncologic hepatectomy with the assigned Pringle duration. * Receive routine perioperative assessments, including laboratory tests and clinical evaluations. * Attend follow-up visits at approximately 6 months, 1 year, and 3 years after surgery.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 600 (estimated)
- First submitted
- 14 Nov 2025
- Start date
- 1 Dec 2025
- Primary completion date
- 1 Nov 2028
- Lead sponsor
- Medical University of Warsaw
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT07237204
What you commit to
- Study type: Interventional
- Planned participants: 600
- From 1 Dec 2025 to the primary completion date, 1 Nov 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior ablation or chemoembolization of hepatic lesions.
- Prior portal vein branch embolization.
- Concomitant resection of any organ other than the gallbladder during the same operation.
Other
- Liver cirrhosis.
- Liver dysfunction classified as Child-Pugh class B or C.
- Repeat hepatectomy.
- Planned or performed ALPPS procedure.
Who the study is looking for
- Diagnosis of a primary or secondary malignant liver tumor.
- Age \> 18 years.
- Patient deemed eligible for liver resection.
- WHO performance status ≤ 2.
- Ability to provide written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of General, Transplant and Liver Surgery, Medical University of Warsaw Coordinator of this site? Confirm its status | Warsaw | Poland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.