NCT07237555Completed
CVL Risk After Severe Glaucoma Surgery
Comparison of the Likelihood of Side Effects Between Surgical Methods in Patients With Severe Stage Glaucoma
Source: ClinicalTrials.gov · Last updated 10 Sept 2026
Brief summary (registry, in English)
This retrospective cohort study analyzes risk factors for central visual loss (CVL) after severe-stage glaucoma surgery. The primary hypothesis is that 1) visual prognosis is determined primarily by early postoperative intraocular pressure (IOP) stability rather than surgical choice, and 2) the nature of risk (hypotony vs hypertension) is modified by baseline visual reserve. We analyzed outcomes in 523 patients with severe-stage glaucoma who underwent trabeculectomy or Ahmed glaucoma valve (AGV) implantation, focusing on the dichotomous risk profile stratified by baseline visual acuity.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 523 (actual)
- First submitted
- 16 Nov 2025
- Start date
- 27 Nov 2024
- Primary completion date
- 26 Nov 2025
- Lead sponsor
- Gangnam Severance Hospital
- Diseases
- Glaucoma
- NCT number
- NCT07237555
What you commit to
- Study type: Observational
- Participants enrolled: 523
- From 27 Nov 2024 to the primary completion date, 26 Nov 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- 1\. Patients who were unable to undergo visual field testing due to poor preoperative visual acuity.
- 2\. Patients with central visual field defects caused by retinal or neurological diseases other than glaucoma.
- 3\. Patients with false-positive or false-negative responses ≥33% on visual field testing.
Who the study is looking for
- 1\. Patients who underwent trabeculectomy or Ahmed glaucoma valve implantation at Yonsei Medical Center between January 2005 and October 2024.
- 2\. Glaucoma patients who underwent static quantitative perimetry (visual field test) before and after surgery.
- 3\. Patients with a preoperative Mean Deviation (MD) of ≤ -20 dB.
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Gangnam Severacne Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.