NCT07240272Completed
tACS Modulates Speech and Cognitive Impairments in People With PD by Targeting the Medial Frontal Cortex
Modulation of Executive Functions and Speech in Parkinson's Disease by Theta tACS Targeted at the Medial Frontal Cortex
Source: ClinicalTrials.gov · Last updated 20 Nov 2025
Brief summary (registry, in English)
This clinical trial aims to study whether transcranial alternating current stimulation (tACS) applied to the medial frontal cortex (MFC) can improve speech and cognitive function in people with Parkinson's disease (PD), and to evaluate the safety of tACS. The main goals are to answer the following questions: 1. Can tACS stimulation of the MFC improve executive functions in people with PD (such as reasoning, planning, inhibition, and complex problem-solving)? 2. Can it improve the integration of auditory information and speech motor control during communication? Researchers will compare the effects of real tACS versus sham (placebo) stimulation to see if real stimulation leads to better speech and cognitive outcomes in PD patients. Participants will: 1. Receive one extra 20-minute session of either real or sham tACS each day for two weeks 2. Attend clinic visits before stimulation, right after the 2-week period, and again at 1 month and 3 months for assessments and tests 3. Have their executive function scores, speech performance, and related brain activity recorded
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 28 (actual)
- First submitted
- 26 Sept 2025
- Start date
- Aug 2023
- Primary completion date
- May 2025
- Lead sponsor
- Ke Dong, MD
- Diseases
- Parkinson disease
- NCT number
- NCT07240272
What you commit to
- Study type: Interventional
- Participants enrolled: 28
- From Aug 2023 to the primary completion date, May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Pregnancy.
- Any contraindications to electrical stimulation.
Who the study is looking for
- Clinical diagnosis of Parkinson's disease.
- Aged 35-80 years.
- Absence of non-PD neurological disorders.
- No hearing impairment, dementia, psychiatric abnormalities, or history of neurosurgical treatment.
Age in the registry: 35 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University Coordinator of this site? Confirm its status | Guangzhou | China | Unknown status |
Related publications
- Theta tACS Over the Medial Frontal Cortex Modulates Executive Function in Parkinson's Disease: A Randomized, Sham-Controlled Study.CNS Neurosci Ther · 2026 · PMID 42499269
This page is information, not medical advice. Discuss any trial with your doctor.