NCT07240298Completed
Comparison of Triglyceride-Glucose Index and Atherogenic Indices Between Patients With Lipedema and Obese Controls
Comparison of Triglyceride-Glucose Index and Atherogenic Indices Between Patients With Lipedema and Obese Controls: A Cross-Sectional Study
Source: ClinicalTrials.gov · Last updated 20 Nov 2025
Brief summary (registry, in English)
Women aged 18-75 years with a clinical diagnosis of lipedema and an obese control group will be included in the study. Sociodemographic and clinical data (age, height, weight, medications, etc.) of the participants will be recorded. For laboratory evaluation, fasting blood test results obtained within the last three months (including fasting glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides) will be used. Based on these parameters, metabolic and atherogenic risk indicators such as the Triglyceride-Glucose Index (TyG), TyG-BMI, Atherogenic Index of Plasma (AIP), Atherogenic Coefficient (AC), Castelli Risk Index I (CRI-I), and Castelli Risk Index II (CRI-II) will be calculated. No additional biochemical tests will be collected from participants; analyses will be performed using existing laboratory results.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 140 (actual)
- First submitted
- 16 Nov 2025
- Start date
- 10 Oct 2025
- Primary completion date
- 10 Nov 2025
- Lead sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
- Diseases
- Obesity
- NCT number
- NCT07240298
What you commit to
- Study type: Observational
- Participants enrolled: 140
- From 10 Oct 2025 to the primary completion date, 10 Nov 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Received injection therapy or physical therapy for the lower extremities within the past 6 months
Other illness
- Presence of rheumatologic diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) or active malignancy
- Neurological disorders (e.g., polyneuropathy, multiple sclerosis, history of stroke)
- History of lower extremity surgery or major trauma within the past 6 months
- Active infection or dermatological disease affecting the lower extremities
- History of significant venous insufficiency or acute deep vein thrombosis (DVT)
Lab values
- Use of medications that routinely affect lipid or glucose metabolism: statins, fibrates, niacin, ezetimibe, high-dose omega-3 supplements, GLP-1 receptor agonists, SGLT2 inhibitors, or systemic corticosteroids (regular use within the past 3 months)
Other
- Pregnancy or lactation
- Alcohol or substance abuse
- Smoking
Who the study is looking for
- Clinically diagnosed with lipedema
- Obese control group with BMI ≥30 kg/m² who do not meet lipedema criteria
- Aged between 18 and 75 years
- Availability of fasting lipid profile and fasting glucose tests within the past 3 months
- Provided voluntary informed consent
Age in the registry: 18 years to 75 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Istanbul Physical Medicine Rehabilitation Training and Research Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.