NCT07240441Recruiting
Endo-ePIcardial Versus Endocardial Only Catheter Ablation for ISchemic Driven Ventricular Tachycardia (EPISODE VT)
Endo-ePIcardial Versus Endocardial Only Catheter Ablation for ISchemic Driven Ventricular Tachycardia (EPISODE VT) - Multicenter, Prospective, Randomized Trial
Source: ClinicalTrials.gov · Last updated 20 Nov 2025
Brief summary (registry, in English)
The EPISODE VT trial is designed to compare efficacy and safety of two modalities for interventional treatment - endocardial ablation and endo-epicardial ablation in a population of patients with post myocardial infarction (ICD 10 - I25.2) ventricular tachycardias (ICD 10 - I47.2), who are protected by an implantable cardioverter-defibrilator (ICD) and meet study inclusion criteria.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 220 (estimated)
- First submitted
- 14 Nov 2025
- Start date
- 3 Feb 2025
- Primary completion date
- 30 Nov 2030
- Lead sponsor
- MEDICOVER SP Z O.O.
- Diseases
- Coronary artery disease
- NCT number
- NCT07240441
What you commit to
- Study type: Interventional
- Planned participants: 220
- From 3 Feb 2025 to the primary completion date, 30 Nov 2030
- 9 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous heart surgery.
Other illness
- Acute conditions that prevent ablation (including active infection, overt hyperthyroidism and others listed below).
- Active neoplastic disease.
- Heart failure with NYHA IV.
Lab values
- Left ventricle ejection fraction \< 20%.
- Renal failure (eGFR \< 20 mL/min/1.73m2).
Other
- Obesity with BMI \> 40 kg/m2.
- Pregnancy or breastfeeding.
- Fresh ballot thrombus in the left ventricle.
- Suspicion of massive adhesions in the pericardium that may impede pericardial puncture.
- Ablation of the post-infarction VT in the left ventricle in medical history.
- Life expectancy less than 12 months.
Who the study is looking for
- Status after myocardial infarction (minimum 3 months before inclusion in the study).
- Documented post-infarction VT or VF.
- Implantable ICD (at least 2 weeks before ablation) or CRT-D (at least 2 months before ablation).
- A history of at least one from below:
- One or more high energy interventions.
- Three or more adequate antitachycardia pacing therapies, including one symptomatic.
- Three or more episodes of VT in 24 hours (interrupted by ATP or shock) - electrical storm.
- Sustained VT recorded on ECG with a cycle length longer than the ICD detection threshold.
- Age between 18 and 85 years.
- Signed informed consent to participate in the study.
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (9)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital No. 1 in Bydgoszcz Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Not yet recruiting |
| University Clinical Center based in Gdańsk Coordinator of this site? Confirm its status | Gdansk | Poland | Not yet recruiting |
| Independent Public Health Care Facility University Hospital in Krakow Coordinator of this site? Confirm its status | Krakow | Poland | Not yet recruiting |
| University Clinical Hospital in Poznań Coordinator of this site? Confirm its status | Poznan | Poland | Not yet recruiting |
| University Clinical Hospital No. 2 PUM in Szczecin Coordinator of this site? Confirm its status | Szczecin | Poland | Not yet recruiting |
| Medical University of Warsaw Coordinator of this site? Confirm its status | Warsaw | Poland | Recruiting |
| National Institute of Cardiology Coordinator of this site? Confirm its status | Warsaw | Poland | Not yet recruiting |
| Medicover Hospital Coordinator of this site? Confirm its status | Warsaw | Poland | Recruiting |
| Grochowski Hospital named after Dr. Rafał Masztak, MD Coordinator of this site? Confirm its status | Warsaw | Poland | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.