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NCT07241494Completed

Evaluation of Clinical Pharmacy Services and Drug Use in Renal Impairment.

Investigation of Drug Use and Evaluation of Clinical Pharmacy Services in Patients With Renal Impairment.

Source: ClinicalTrials.gov · Last updated 1 Dec 2025

Brief summary (registry, in English)

Clinical pharmacy services aim to optimise medication use, enhance patient outcomes, and reduce the risk of drug-related harm through patient-centred pharmaceutical care. In hospital settings, clinical pharmacists collaborate with physicians and other healthcare professionals as part of a multidisciplinary team to identify, prevent, and resolve drug-related problems (DRPs). Pharmacist interventions are defined as any action initiated by a pharmacist that directly contributes to patient management or results in a modification of medication therapy. The clinical and economic benefits of such interventions have been widely recognised in various healthcare environments. This quasi-experimental study aims to investigate the impact of clinical pharmacy services on drug use and the management of DRPs in patients with renal impairment admitted to the general internal medicine ward. The study also evaluates the contribution of the clinical pharmacist to optimising the use of drugs that require renal dose adjustment. The study was conducted in a university hospital and included three consecutive patient groups: observation (control), education, and intervention. In the observation group, no pharmacist intervention was performed. In the education group, physicians received a structured educational presentation on renal dose adjustment for commonly prescribed medications. In the intervention group, the clinical pharmacist actively participated in daily ward rounds, identified and resolved DRPs, and provided recommendations to physicians. DRPs were classified using the Pharmaceutical Care Network Europe (PCNE) classification version 9.1. This study evaluates whether the integration of a clinical pharmacist into the healthcare team can improve the quality of pharmacotherapy, reduce DRPs-particularly those associated with renal dysfunction-and enhance patient safety and outcomes in hospitalised patients.

Status (registry)
Completed
Study type
Interventional
Enrollment
160 (actual)
First submitted
17 Nov 2025
Start date
31 Oct 2021
Primary completion date
31 Oct 2023
Lead sponsor
Istanbul University - Cerrahpasa
NCT number
NCT07241494

What you commit to

  • Study type: Interventional
  • Participants enrolled: 160
  • From 31 Oct 2021 to the primary completion date, 31 Oct 2023
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Not receiving any medication that requires renal dose adjustment.

Lab values

  • eGFR value of 60 mL/min/1.73 m² or higher.

Age

  • Age under 18 years.

Other

  • Hospital stay shorter than 48 hours.
  • Refusal or inability to provide informed consent.
  • Lack of sufficient cognitive ability to participate in the study.

Who the study is looking for

  • Hospitalised in the General Internal Medicine ward with an estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m².
  • Hospital stay of at least 48 hours.
  • Receiving at least one medication that requires dose adjustment in renal impairment.
  • Age 18 years or older.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Bezmialem Vakif University
Coordinator of this site? Confirm its status
IstanbulTurkey (Türkiye)Unknown status

This page is information, not medical advice. Discuss any trial with your doctor.