NCT07242105Recruiting
Optimizing Brain Excitability in Depression
Optimized Methods for Measuring Brain Excitability in Depression
Source: ClinicalTrials.gov · Last updated 10 Feb 2026
Brief summary (registry, in English)
The goal of this study is to improve depression treatment by establishing reliable prefrontal excitability markers through Targeting with Automated Real-time Guidance for Enhancing TEPs (TARGET).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 145 (estimated)
- First submitted
- 11 Nov 2025
- Start date
- 23 Oct 2025
- Primary completion date
- 30 Aug 2029
- Lead sponsor
- Stanford University
- Diseases
- Depression
- NCT number
- NCT07242105
What you commit to
- Study type: Interventional
- Planned participants: 145
- From 23 Oct 2025 to the primary completion date, 30 Aug 2029
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- A prior history of Electroconvulsive Therapy (ECT) failure
Other illness
- History of head trauma with loss of consciousness
- History of seizures or on medications that reduce seizure threshold (e.g., olanzapine, chlorpromazine, lithium)
- Neurological or uncontrolled medical disease
- Any unstable medical condition
- Diagnosis of psychotic or bipolar disorder
- History of suicide attempt in the past year
Other
- Those with a contraindication for MRIs (e.g. implanted metal)
- Active substance abuse
- Currently pregnant or breastfeeding
- Repetitive Transcranial Magnetic Stimulation (rTMS) treatment in the past six months
Who the study is looking for
- Men and women, ages 18 to 65
- Diagnosis of major depressive disorder, assessed through a Structured Clinical Interview for DSM-5 (SCID-5)
- In a current depressive episode, assessed through a Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (DSM-5) (SCID-5)
- Moderate-to-severe depression as indicated by a score between 11-20 on the Quick Inventory of Depressive Symptoms (QIDS)
- Must comprehend English well to ensure adequate comprehension of the EEG and TMS instructions, and of clinical scales
- No current or history of neurological disorders
- No seizure disorder or risk of seizures
- Neurosurgical patients: Men and women ages 18-65 with medication-refractory epilepsy who are admitted for phase II intracranial monitoring to detect a seizure focus will be considered appropriate for this study. Participants must have the intellectual capacity to understand the consent process and agree to the study.
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Iowa Coordinator of this site? Confirm its status | Iowa City | United States | Recruiting |
| Stanford University Coordinator of this site? Confirm its status | Stanford | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.