NCT07243015Recruiting
Detection of Minimal Residual Disease Using Exosomal miRNA Distant Metastasis Markers
Exosomal microRNA-based Analysis for Early detectIon of Gastric Cancer Hidden-recurrence Traces
Source: ClinicalTrials.gov · Last updated 6 Jul 2026
Brief summary (registry, in English)
Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Even in patients undergoing curative surgery for non-metastatic disease, postoperative recurrence frequently occurs due to undetected minimal residual disease (MRD). This study aims to establish a highly sensitive and specific liquid biopsy assay using exosomal microRNAs (exo-miRNAs) to detect MRD and predict distant metastasis before clinical recurrence.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 17 Nov 2025
- Start date
- 15 Jan 2025
- Primary completion date
- 18 Jun 2028
- Lead sponsor
- City of Hope Medical Center
- Diseases
- Gastric and esophageal cancer
- NCT number
- NCT07243015
What you commit to
- Study type: Observational
- Planned participants: 500
- From 15 Jan 2025 to the primary completion date, 18 Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Received neoadjuvant chemotherapy without postoperative follow-up.
Other illness
- Presence of synchronous or metachronous malignancies.
Other
- Insufficient plasma volume or RNA quality for exosomal extraction.
- Lack of consent or incomplete clinicopathologic data.
Who the study is looking for
- Histologically confirmed gastric adenocarcinoma.
- Underwent curative-intent resection (R0).
- Availability of pre- and postoperative plasma samples.
- Documented clinical follow-up data (recurrence/metastasis status).
- Provided written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| City of Hope Medical Center Coordinator of this site? Confirm its status | Duarte | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.