NCT07244315Completed
Cervical Cancer Screening of Postmenopausal Women in Low- and Middle-income Countries Using HPV Self-sampling and Triage by Genotyping and Cytology
Source: ClinicalTrials.gov · Last updated 21 Jan 2026
Brief summary (registry, in English)
Cervical cancer remains a major cause of mortality in low- and middle-income countries, especially among women aged 50 years and older who are often under-screened. In post-menopausal women, the transformation zone is frequently not visible, which makes visual inspection with acetic acid (VIA) less reliable and limits access to adequate screening. Human papillomavirus (HPV) self-sampling offers a simple and acceptable primary screening method, but effective triage options for HPV-positive women in this age group remain limited. This study aims to evaluate the feasibility and diagnostic performance of a screening strategy based on HPV self-sampling followed by Pap cytology triage among HPV-positive women aged 50 to 65 years in Cameroon. Approximately 500 women will be invited to perform self-HPV testing at the Mifi District Hospital. HPV-positive women will undergo Pap cytology, endocervical brushing and digital cervicography, and eligible participants will receive treatment with thermal ablation at Bafoussam Regional Hospital. Follow-up at 12 months will include repeat HPV testing, cytology, and endocervical brushing. The primary outcome is the diagnostic accuracy of HPV + cytology triage for detecting CIN2+. Secondary outcomes include prevalence of high-risk HPV, treatment outcomes, acceptability, and adherence to follow-up.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 500 (actual)
- First submitted
- 17 Nov 2025
- Start date
- 1 Jun 2024
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- University Hospital, Geneva
- Diseases
- Cervical cancer
- NCT number
- NCT07244315
What you commit to
- Study type: Observational
- Participants enrolled: 500
- From 1 Jun 2024 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Women with a condition that interfere with visualization of the cervix;
- Women with vaginal bleeding outside the menstrual period;
- Women with a history of cervical cancer;
- Women screened for cervical cancer in the last 5 years or in the last 3 years if HIV-positive;
- Women in the terminal phase of an illness.
Other
- Women who is pregnant;
- Women who have had a total hysterectomy;
Who the study is looking for
- Women aged 50 to 65 years old;
- Ability to understand study procedures and accepting voluntarily to participate by signing an informed consent form (ICF).
Age in the registry: 50 years to 65 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Bafoussam Regional Hospital Coordinator of this site? Confirm its status | Bafoussam | Cameroon | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.