NCT07245056Completed
Fetal Fornix and Hippocampus in Pregnant Women With Early-Onset Preeclampsia
Evaluation of the Fetal Fornix and Hippocampus in Pregnant Women With Early-Onset Preeclampsia
Source: ClinicalTrials.gov · Last updated 15 Sept 2026
Brief summary (registry, in English)
Since early-onset preeclampsia (EOPE) is commonly associated with inadequate placentation, placental insufficiency, chronic fetal hypoxia, oxidative stress, and heightened inflammation, these pathological processes may adversely affect hippocampal neuronal development and maturation of axonal pathways such as the fornix. These mechanisms support our hypothesis that fetal fornix and hippocampus dimensions may be reduced in pregnancies complicated by EOPE, forming the scientific basis of our study. Previous research has suggested a potential link between preeclampsia (PE) and altered neurocognitive development. However, no studies to date have specifically evaluated the relationship between EOPE and fetal fornix or hippocampus dimensions. Therefore, the objective of our study is to assess fetal fornix and hippocampus measurements in pregnant women with early-onset preeclampsia compared with healthy controls.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 84 (actual)
- First submitted
- 15 Nov 2025
- Start date
- 1 Dec 2025
- Primary completion date
- 1 Jul 2026
- Lead sponsor
- Ankara Etlik City Hospital
- NCT number
- NCT07245056
What you commit to
- Study type: Interventional
- Participants enrolled: 84
- From 1 Dec 2025 to the primary completion date, 1 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Chronic medication use
Other illness
- Presence of chronic or significant comorbid conditions other than maternal early-onset preeclampsia, including: Chronic, mental, or physical illnesses, severe renal, hepatic, or gastrointestinal acute or chronic inflammatory diseases, hyperthyroidism or hypothyroidism, chronic hypertension, type 1 or type 2 diabetes mellitus, history of polycystic ovary syndrome (PCOS), history of malignancy
Other
- Multiple pregnancies
- Fetal congenital or chromosomal anomalies
- Tobacco or alcohol use during pregnancy
- Maternal late-onset preeclampsia (≥34 weeks gestation)
Who the study is looking for
- Women aged 18-45 years
- Gestational age between 20 and 34 weeks
- Diagnosis of early-onset preeclampsia (EOPE)
- Singleton pregnancy
Age in the registry: 18 years to 45 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ankara Etlik City Hospital Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.