NCT07245589Not yet recruiting
Evaluation of the Clinical Contribution of Quantitative MRI in Neuro-imaging
Development of Quantitative MRI Neuroimaging Protocols at High Fields (3 Tesla) and Ultra-high Fields (7 Tesla) for Clinical Evaluation: Application to Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 24 Nov 2025
Brief summary (registry, in English)
This study aims to develop the use of a quantitative MRI (qMRI) approach in neuroimaging for MS patients. To achieve this task the main goals of this study will be: * to standardize and optimize qMRI protocols (acquisition time, sensitivity) * to acquire ranges of normative values of qMRI parameters as a function of age and sex at high fields (3 Tesla) and ultra-high fields (UHF for ultra-high field, 7 Tesla) * To develop integrated tools for image processing and the generation of normative models of the healthy brain normative values * To assess the clinical feasibility and the multicenter validation of the multiparametric tools proposed in the case of application to MS.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 272 (estimated)
- First submitted
- 2 Oct 2025
- Start date
- 1 Dec 2025
- Primary completion date
- 30 Apr 2028
- Lead sponsor
- Assistance Publique Hopitaux De Marseille
- Diseases
- Multiple sclerosis
- NCT number
- NCT07245589
What you commit to
- Study type: Interventional
- Planned participants: 272
- From 1 Dec 2025 to the primary completion date, 30 Apr 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- For healthy subjects :
- Subject presenting a contraindication to performing an MRI: pacemaker, presence of metal implants, claustrophobia.
- Subject unable to maintain a supine position for a prolonged period
- Subject in a period of exclusion from another research protocol at the time of signing consent/non-opposition form
- Subjects covered by articles L1121-5 to 1121-8 of the Public Health Code (minor patient, adult patient under guardianship or curatorship, patient deprived of liberty, pregnant or breastfeeding woman)
- For MS patients
- Subject presenting a contraindication to performing an MRI: pacemaker, presence of metal implants, claustrophobia.
- Subject unable to maintain a supine position for a prolonged period
- Subject in a period of exclusion from another research protocol at the time of signing consent/non-opposition form
- Subjects covered by articles L1121-5 to 1121-8 of the Public Health Code (minor patient, adult patient under guardianship or curatorship, patient deprived of liberty, pregnant or breastfeeding woman)
Who the study is looking for
- For healthy volunteers :
- Male or female aged 20 to 50
- Subject with no history of previous or concomitant neurological and psychiatric diseases at the time of inclusion
- Subject without a history of traumatic brain injury
- Subject with no vascular history (arterial hypertension, stroke) or concomitant at the time of its inclusion
- Subject has no history of chronic drug and/or alcohol abuse
- Subject having received information regarding the study and having signed an informed consent
- Beneficiary or entitled person to a social security scheme
- For MS patients
- Male or female aged 18 to 52
- Patient diagnosed with MS according to the
- criteria of McDonald 2017
- Patient presenting a maximum EDSS of 6
- Patient with MS for less than 10 years of evolution
- Patient having received information regarding the study and having signed an informed consent
- Patient beneficiary or entitled to a plan of social security
Age in the registry: 18 years to 52 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hôpital Gui de Chauliac Coordinator of this site? Confirm its status | Montpellier | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.