NCT07246213Recruiting
CAYA Cancer Retrospective Cohort Study
Improving Cancer Outcomes for Children, Adolescents, and Young Adults: A Multicenter Retrospective Cohort Study on Treatment Failure and Toxicity in Low- and Middle-Income Countries
Source: ClinicalTrials.gov · Last updated 29 Sept 2026
Brief summary (registry, in English)
Despite advances in cancer treatment, significant disparities in outcomes persist between high-income countries (HICs) and low-and middle-income countries (LMICs). Around 80% of children with cancer live in LMICs, where they face challenges such as delayed diagnosis, misdiagnosis, comorbidities, distance to treatment, financial barriers, and limited access to risk-adapted therapies. Acute lymphoblastic leukemia(ALL)/lymphoblastic lymphoma(LBL), for example, is one of the greatest success stories in pediatric oncology, however, such improvements are not evenly distributed worldwide, and the outcomes for leukemia patients are poorer in LMICs compared to HICs, primarily due to reduced access to quality healthcare. This study aims to assess cancer treatment outcomes in LMICs, focusing on acute lymphoblastic leukemia/lymphoblastic lymphoma. The findings will inform future studies to implement evidence-based interventions that improve care quality and reduce treatment failures through targeted strategies.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 18000 (estimated)
- First submitted
- 17 Nov 2025
- Start date
- 4 Jun 2025
- Primary completion date
- 4 Jun 2028
- Lead sponsor
- Resonance, Inc.
- NCT number
- NCT07246213
What you commit to
- Study type: Observational
- Planned participants: 18000
- From 4 Jun 2025 to the primary completion date, 4 Jun 2028
- 7 sites in 6 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Subjects meeting any of the following criteria will be excluded from this registry:
- Patients who only visited the participating center for:
- Consultation without subsequent primary anti-cancer treatment at the participating center
- Pathology, radiology, or other diagnostic evaluations without treatment
Who the study is looking for
- Subjects must meet all the following criteria to be included in this registry:
- Participants must be willing and able to provide informed consent prior to enrollment in the registry.
- For minors or individuals unable to provide informed consent, assent must be obtained along with consent from a legal guardian.
- Note: Exemption applies to this criterion when waiver of informed consent/assent is granted by Institutional Review Board(IRB)/Independent Ethics Committee(IEC)/Competent Authorities(CAs).
- A confirmed diagnosis of any type of cancer within the 15 years prior to the site's activation date.
- Age 0 to 21 years at the time of diagnosis.
- Received substantial anti-cancer treatment at the participating center, including but not limited to:
- Chemotherapy
- Surgery
- Radiation therapy
- Immunotherapy
- Medical records are available and accessible for review
Age in the registry: 0 years to 21 years · Sex: All · Does not accept healthy volunteers
Sites (7)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Yeolyan Center for Cancer and Blood Disorders Coordinator of this site? Confirm its status | Yerevan | Armenia | Recruiting |
| The Children's Cancer Hospital Egypt 57357 Coordinator of this site? Confirm its status | Cairo | Egypt | Not yet recruiting |
| Unidad Nacional de Oncología Pediátrica (UNOP) Coordinator of this site? Confirm its status | Guatemala City | Guatemala | Recruiting |
| Hospital Mario Catarino Rivas Coordinator of this site? Confirm its status | San Pedro Sula | Honduras | Recruiting |
| Hospital Escuela Coordinator of this site? Confirm its status | Tegucigalpa | Honduras | Recruiting |
| Fundación Ayúdame a Vivir Coordinator of this site? Confirm its status | El Salvador | El Salvador | Recruiting |
| Kilimanjaro Christian Medical Center Coordinator of this site? Confirm its status | Moshi | Tanzania | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.