NCT07247084RecruitingPhase 4
A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
A Phase 4 Multicenter, Randomized, Open-Label, Interventional Study With Pragmatic Elements Investigating the Effectiveness of Tirzepatide Once Weekly Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes in a Real-World Setting
Source: ClinicalTrials.gov · Last updated 9 Sept 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate tirzepatide within a real-world setting to assess body weight loss and incidence of type 2 diabetes in adults without diabetes who have obesity and at least one weight-related comorbid condition. Eligible participants must be registered patients at a participating site. Participation in the study will last about 260 weeks.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 3000 (estimated)
- First submitted
- 19 Nov 2025
- Start date
- 24 Nov 2025
- Primary completion date
- Jul 2029
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT07247084
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 3000
- From 24 Nov 2025 to the primary completion date, Jul 2029
- 30 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have had a change in body weight of greater than 5 kilograms (11 pounds) within 90 days prior to screening
Other illness
- Have type 1 diabetes, type 2 diabetes, or any other types of diabetes
Who the study is looking for
- Have a body mass index ≥30 and ≤34.9 kilogram per square meter (kg/m2)
- Have an increased waist to height ratio (defined by \>0.5)
- Have at least one weight related comorbid condition
- Have had at least one attempt to lose weight with lifestyle intervention (diet and physical activity)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (30)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| P91604 St John's Medical Centre Coordinator of this site? Confirm its status | Altrincham | United Kingdom | Not yet recruiting |
| P89008 Ashton Medical Group Coordinator of this site? Confirm its status | Ashton-under-Lyne | United Kingdom | Recruiting |
| Y02319 SSP Bolton General Practice Coordinator of this site? Confirm its status | Bolton | United Kingdom | Not yet recruiting |
| P83012 Tower Family Healthcare Coordinator of this site? Confirm its status | Bury | United Kingdom | Not yet recruiting |
| P88007 Cheadle Hulme Medical Group (was Cheadle Hulme Health Centre) (Bridge House) Coordinator of this site? Confirm its status | Cheshire | United Kingdom | Not yet recruiting |
| P91014 Washway Road Medical Centre Coordinator of this site? Confirm its status | Cheshire | United Kingdom | Not yet recruiting |
| Y02790 SSP Bolton Medical Centre Coordinator of this site? Confirm its status | Great Lever | United Kingdom | Not yet recruiting |
| P89002 The Brooke Surgery Coordinator of this site? Confirm its status | Hyde SK14 | United Kingdom | Recruiting |
| P87019 Silverdale Medical Practice Coordinator of this site? Confirm its status | Manchester | United Kingdom | Recruiting |
| P84034 Barlow Medical Centre Coordinator of this site? Confirm its status | Manchester | United Kingdom | Not yet recruiting |
| P84068 Chorlton Family Practice Coordinator of this site? Confirm its status | Manchester | United Kingdom | Not yet recruiting |
| P84017 Ladybarn Group Practice Coordinator of this site? Confirm its status | Manchester | United Kingdom | Not yet recruiting |
| P86004 Peterloo Medical Centre Coordinator of this site? Confirm its status | Manchester | United Kingdom | Recruiting |
| P84678 Didsbury Medical Centre Coordinator of this site? Confirm its status | Manchester | United Kingdom | Not yet recruiting |
| P84012 Northenden Group Practice Coordinator of this site? Confirm its status | Manchester | United Kingdom | Not yet recruiting |
| P83025 St Gabriels Medical Centre Coordinator of this site? Confirm its status | Manchester | United Kingdom | Not yet recruiting |
| P84630 The Arch Medical Practice Coordinator of this site? Confirm its status | Manchester | United Kingdom | Recruiting |
| P92620 SSP Ince Surgery (Lower Ince) Coordinator of this site? Confirm its status | Manchester | United Kingdom | Not yet recruiting |
| P84035 Bodey Medical Centre Coordinator of this site? Confirm its status | Manchester | United Kingdom | Recruiting |
| P91006 Urmston Group Practice Coordinator of this site? Confirm its status | Manchester | United Kingdom | Not yet recruiting |
| P85011 CH Medical Practice Coordinator of this site? Confirm its status | Oldham | United Kingdom | Recruiting |
| P85010 Woodlands Medical Practice Coordinator of this site? Confirm its status | Oldham | United Kingdom | Recruiting |
| P86022 Stonefield Street Surgery Coordinator of this site? Confirm its status | Rochdale | United Kingdom | Recruiting |
| P91013 Boundary House Medical Centre Coordinator of this site? Confirm its status | Sale | United Kingdom | Not yet recruiting |
| P91021 Firsway Health Centre Coordinator of this site? Confirm its status | Sale | United Kingdom | Not yet recruiting |
| P87027 Langworthy Medical Practice Coordinator of this site? Confirm its status | Salford | United Kingdom | Recruiting |
| P88632 Stockport Medical Group Coordinator of this site? Confirm its status | Stockport | United Kingdom | Not yet recruiting |
| P87025 The Lakes Medical Practice Coordinator of this site? Confirm its status | Swinton | United Kingdom | Recruiting |
| P87016 The Sides Medical Centre Coordinator of this site? Confirm its status | Swinton | United Kingdom | Recruiting |
| Y02322 SSP Leigh Family Practice Coordinator of this site? Confirm its status | Wigen | United Kingdom | Not yet recruiting |
Related publications
- SURMOUNT-REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity.Obesity (Silver Spring) · 2026 · PMID 42297568
This page is information, not medical advice. Discuss any trial with your doctor.